Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets.

IF 2.8 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Tengfei Zhao, Yangyang Li, Huixue Liu, Chongxin Tong
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引用次数: 0

Abstract

Background: Sexual dysfunction and cervical cancer are genetically and molecularly two complex health problems. Here, we integrate genetic inference and single-cell expression analysis to identify potential genetic targets for sexual dysfunction and cervical cancer, and assess causality of these targets utilizing Mendelian randomization approaches.

Methods: We performed a genome-wide association study (GWAS) to identify genetic variants associated with sexual dysfunction and cervical cancer. Next, we examined the cellular landscape of these variation regions based on scRNAseq data.

Results: The study identified several genetic variants that are correlated with sexual dysfunction and cervical cancer, respectively, and these differentially expressed in reproductive and cervical cells. Two-Gene Combination Panel Increased expression of the WISP1 gene was detected in cervical cancer tissues. Twas most highly expressed in T cells, and least well- when cells were proliferating.

Conclusions: The study integrates genetics with single-cell expression to nominate genetic targets for sexual dysfunction and cervical cancer and establishes causal support from Mendelian randomization approach.

勃起功能障碍和宫颈癌靶点的单细胞和表达分析。
背景:性功能障碍和宫颈癌是遗传和分子上两种复杂的健康问题。在这里,我们将遗传推断和单细胞表达分析结合起来,确定性功能障碍和宫颈癌的潜在遗传靶点,并利用孟德尔随机化方法评估这些靶点的因果关系。方法:我们进行了一项全基因组关联研究(GWAS),以确定与性功能障碍和宫颈癌相关的遗传变异。接下来,我们基于scRNAseq数据研究了这些变异区域的细胞景观。结果:研究确定了几个与性功能障碍和宫颈癌相关的基因变异,这些变异在生殖细胞和宫颈细胞中差异表达。在宫颈癌组织中检测到WISP1基因表达升高。它在T细胞中表达最多,在细胞增殖时表达最少。结论:该研究将遗传学与单细胞表达结合起来,确定了性功能障碍和宫颈癌的遗传靶点,并建立了孟德尔随机化方法的因果支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Discover. Oncology
Discover. Oncology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.40
自引率
9.10%
发文量
122
审稿时长
5 weeks
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