Sarcomatous transformation of IDH-mutant astrocytoma matching to methylation class oligosarcoma following embolization, a case report.

IF 6.2 2区 医学 Q1 NEUROSCIENCES
Ryan Landvater, Arushi Tripathy, Edwin Nieblas-Bedolla, Lina Shao, Kyle Conway, Wajd Al-Holou, Sean P Ferris
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引用次数: 0

Abstract

The mesenchymal transformations of infiltrating gliomas are uncommon events. This is particularly true of IDH-mutant astrocytomas and oligodendrogliomas, in which mesenchymal transformation is exceedingly rare. oligosarcoma is a newly recognized methylation class (MC) that represents transformed 1p/19q co-deleted oligodendrogliomas, but recent studies indicate it may be non-specific. Herein we report the diffuse sarcomatous transformation of a multifocal recurrent astrocytoma from a precursor IDH-mutant astrocytoma, CNS WHO grade 3, in a young patient following embolization therapy and matching to MC oligosarcoma. The sarcomatous recurrence and original tumor showed identical 17q breakpoints with loss of heterozygosity of TP53. Both lack the defining 1p/19q co-deletion or copy-neutral heterozygosity of an oligodendroglioma and oligosarcoma. The findings in this case report both contribute to the apparent heterogeneity of the novel MC oligosarcoma and describe a second reported mesenchymal transformation of an IDH-mutant astrocytoma.

栓塞后idh突变星形细胞瘤与甲基化级少肉瘤相匹配的肉瘤转化1例报告。
浸润性胶质瘤的间质转化并不常见。对于idh突变的星形细胞瘤和少突胶质细胞瘤尤其如此,它们的间充质转化极为罕见。oligosarcoma是一种新发现的甲基化类(MC),代表转化的1p/19q共缺失少突胶质细胞瘤,但最近的研究表明它可能是非特异性的。在此,我们报告了一名年轻患者在栓塞治疗后与MC少肉瘤匹配的多灶性复发星形细胞瘤,从前体idh突变星形细胞瘤,CNS WHO分级3。肉瘤复发与原发肿瘤显示相同的17q断点,TP53杂合性缺失。两者都缺乏少突胶质细胞瘤和少突肉瘤的定义性1p/19q共缺失或拷贝中性杂合性。本病例的研究结果既有助于新型MC少肉瘤的明显异质性,也描述了idh突变星形细胞瘤的第二种间充质转化。
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来源期刊
Acta Neuropathologica Communications
Acta Neuropathologica Communications Medicine-Pathology and Forensic Medicine
CiteScore
11.20
自引率
2.80%
发文量
162
审稿时长
8 weeks
期刊介绍: "Acta Neuropathologica Communications (ANC)" is a peer-reviewed journal that specializes in the rapid publication of research articles focused on the mechanisms underlying neurological diseases. The journal emphasizes the use of molecular, cellular, and morphological techniques applied to experimental or human tissues to investigate the pathogenesis of neurological disorders. ANC is committed to a fast-track publication process, aiming to publish accepted manuscripts within two months of submission. This expedited timeline is designed to ensure that the latest findings in neuroscience and pathology are disseminated quickly to the scientific community, fostering rapid advancements in the field of neurology and neuroscience. The journal's focus on cutting-edge research and its swift publication schedule make it a valuable resource for researchers, clinicians, and other professionals interested in the study and treatment of neurological conditions.
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