Alpha-synuclein RT-QuIC assay in gastroduodenal and skin biopsies of Parkinson disease patients

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2024-12-21 DOI:10.1002/acn3.52282

Aron Emmi, Angela Mammana, Michele Sandre, Simone Baiardi, Luca Weis, Marcello Rossi, Franco Magliocchetti, Edoardo Savarino, Francesco Paolo Russo, Andrea Porzionato, Miryam Carecchio, Marta Campagnolo, Angelo Antonini, Piero Parchi

引用次数: 0

Abstract

In this study, we compared the value of pathological alpha-synuclein (αSyn) seed amplification assay (SAA) in gastric and duodenal biopsies with skin biopsies in Parkinson disease (PD) patients with different disease duration. The accuracy of αSyn SAA was 87.7% in skin, 67.4% in duodenum, and 80.0% in gastric biopsies, with significantly higher sensitivity in advanced PD (skin: 81.8%; gastric: 88.9%; duodenal 58.8%). Misfolded αSyn was detected with higher sensitivity in advanced PD across all matrices, likely reflecting the progression of αSyn pathology. The seeding activity was lower in the duodenal than in the gastric wall, indicating differences in αSyn burden.

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帕金森病患者胃十二指肠和皮肤活检中α -突触核蛋白RT-QuIC检测。

本研究比较了病理α -突触核蛋白（αSyn）种子扩增法（SAA）在不同病程帕金森病（PD）患者胃、十二指肠活检和皮肤活检中的应用价值。αSyn SAA在皮肤活检中的准确率为87.7%，十二指肠活检的准确率为67.4%，胃活检的准确率为80.0%，其中晚期PD的敏感性更高(皮肤：81.8%；胃:88.9%;十二指肠58.8%)。在所有基质中，在晚期PD中检测到错误折叠的αSyn具有更高的敏感性，可能反映了αSyn病理的进展。十二指肠的种子活性低于胃壁，说明αSyn负荷量存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.