Highly Efficient Aggregation-Induced Chiral TADF Molecules Exhibiting Prolonged Lifetime in Living Cells under Hypoxic Stress

IF 8 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Danfeng Ye, Guangrong Zheng, Amjad Ali, Glib V. Baryshnikov, Hans Ågren, Shan Li, Xianzhi Chai, Liangliang Zhu
{"title":"Highly Efficient Aggregation-Induced Chiral TADF Molecules Exhibiting Prolonged Lifetime in Living Cells under Hypoxic Stress","authors":"Danfeng Ye,&nbsp;Guangrong Zheng,&nbsp;Amjad Ali,&nbsp;Glib V. Baryshnikov,&nbsp;Hans Ågren,&nbsp;Shan Li,&nbsp;Xianzhi Chai,&nbsp;Liangliang Zhu","doi":"10.1002/adom.202401844","DOIUrl":null,"url":null,"abstract":"<p>Thermally activated delayed fluorescence (TADF) materials have garnered significant attention as potential candidates for biological photoluminescence imaging. However, the achievement of tunable chiral TADF materials through aggregated and self-assembled processes remains a formidable challenge. In this study, four donor–acceptor–donor type chiral TADF molecules, designed by directly linking electron-donating moieties (phenoxazine, phenothiazine or 1-phenyl-1,2,3,4-tetrahydroisoquinoline) with an electron-acceptor unit (diphenyl sulfone), as promising candidates for luminescent imaging applications are presented. The experimental investigation reveals that these chiral TADF materials possess remarkably small Δ<i>E</i><sub>ST</sub> values, promoting efficient reverse intersystem crossing (RISC). Additionally, they exhibit aggregation-induced emission and long-delayed luminescent lifetimes affected by the aggregated and self-assembled state. Moreover, deoxygenation significantly enhances the emission, enabling high-contrast hypoxia probing, which shows great potential for high-contrast photoluminescence imaging in living cells. This work not only offers a molecular design strategy for chiral TADF materials but also extends the diverse biological applications of high-contrast hypoxia detection in the biological field.</p>","PeriodicalId":116,"journal":{"name":"Advanced Optical Materials","volume":"12 36","pages":""},"PeriodicalIF":8.0000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Optical Materials","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adom.202401844","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Thermally activated delayed fluorescence (TADF) materials have garnered significant attention as potential candidates for biological photoluminescence imaging. However, the achievement of tunable chiral TADF materials through aggregated and self-assembled processes remains a formidable challenge. In this study, four donor–acceptor–donor type chiral TADF molecules, designed by directly linking electron-donating moieties (phenoxazine, phenothiazine or 1-phenyl-1,2,3,4-tetrahydroisoquinoline) with an electron-acceptor unit (diphenyl sulfone), as promising candidates for luminescent imaging applications are presented. The experimental investigation reveals that these chiral TADF materials possess remarkably small ΔEST values, promoting efficient reverse intersystem crossing (RISC). Additionally, they exhibit aggregation-induced emission and long-delayed luminescent lifetimes affected by the aggregated and self-assembled state. Moreover, deoxygenation significantly enhances the emission, enabling high-contrast hypoxia probing, which shows great potential for high-contrast photoluminescence imaging in living cells. This work not only offers a molecular design strategy for chiral TADF materials but also extends the diverse biological applications of high-contrast hypoxia detection in the biological field.

在缺氧应激条件下,高效聚合诱导的手性 TADF 分子在活细胞中表现出更长的寿命
作为生物光致发光成像的潜在候选材料,热激活延迟荧光(TADF)材料备受关注。然而,通过聚集和自组装过程实现可调手性 TADF 材料仍然是一项艰巨的挑战。本研究介绍了四种供体-受体-供体型手性 TADF 分子,它们是通过将电子供体分子(吩噁嗪、吩噻嗪或 1-苯基-1,2,3,4-四氢异喹啉)与电子受体单元(二苯砜)直接连接而设计的,有望用于发光成像应用。实验研究表明,这些手性 TADF 材料具有极小的 ΔEST 值,可促进高效的反向系统间交叉(RISC)。此外,它们还表现出聚集诱导发射以及受聚集和自组装状态影响的长延迟发光寿命。此外,脱氧还能显著增强发射,从而实现高对比度缺氧探测,这在活细胞高对比度光致发光成像方面显示出巨大潜力。这项工作不仅提供了手性 TADF 材料的分子设计策略,还拓展了高对比度缺氧探测在生物领域的多种应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Advanced Optical Materials
Advanced Optical Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-OPTICS
CiteScore
13.70
自引率
6.70%
发文量
883
审稿时长
1.5 months
期刊介绍: Advanced Optical Materials, part of the esteemed Advanced portfolio, is a unique materials science journal concentrating on all facets of light-matter interactions. For over a decade, it has been the preferred optical materials journal for significant discoveries in photonics, plasmonics, metamaterials, and more. The Advanced portfolio from Wiley is a collection of globally respected, high-impact journals that disseminate the best science from established and emerging researchers, aiding them in fulfilling their mission and amplifying the reach of their scientific discoveries.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信