Weijian Song, Man Ho Tse, Yu Kiu Lau, Chi Wai Cheung*, Pui Ying Choy* and Fuk Yee Kwong*,
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引用次数: 0
Abstract
The benzoxazole core, featuring a sterically congested 2,6-disubstituted aryl fragment at the C2 position, exhibits exclusive three-dimensional structures that are essential for particular applications in material science and pharmaceutical development. Despite their importance, the synthesis of these compounds has posed challenges with an efficient preparation strategy still lacking. In this study, we introduced a new indolylphosphine ligand, PCy2-Man-phos, specifically designed to facilitate the C2–H arylation of benzoxazoles with sterically hindered aryl chlorides in general. The excellent functional group compatibility and rich arene substituted pattern enable the creation of highly decorated and sterically demanding 2-arylbenzoxazole frameworks, showing significant potential for diverse synthetic applications.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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