Myocardial infarction and short- or long-term risk of a subsequent cancer diagnosis: A Danish Nationwide Cohort Study.

IF 5.5 2区 医学 Q1 HEMATOLOGY
Jens Sundbøll, Katalin Veres, Frederikke S Troelsen, Morten Würtz, Hans Erik Bøtker, Henrik Toft Sørensen
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引用次数: 0

Abstract

Background: Growing evidence suggests that myocardial infarction (MI) may be a marker of cancer risk, but many aspects of this relation are poorly understood. We therefore examined the short- and long-term risk of incident cancer in patients presenting with MI.

Methods: Using nationwide population-based Danish health registries, we identified all patients with a first-time diagnosis of MI (1995-2021) and followed them for up to 28 years for any subsequent diagnosis of cancer. We computed risks and standardized incidence ratios with 95% confidence intervals (CIs) as the observed number of cancers relative to the expected number based on national cancer incidence rates by sex, age, and calendar year.

Results: Among 185,065 patients diagnosed with MI, we observed 25,315 subsequent cancers. The risk of any cancer was 2.4% after 1 year of follow-up, increasing to 25.8% after 28 years, taking the competing risks of death into account. During the first year of follow-up, the standardized incidence ratio of any cancer was 1.67 (95% CI: 1.62-1.73). The standardized incidence ratio remained moderately elevated during 2-5 years (1.03, 95% CI: 1.01-1.05) and beyond 5 years (1.07, 95% CI: 1.05-1.09). The strongest associations were found for hematological as well as obesity- and smoking-related cancers during the first year of follow-up, whereas primarily the risk of smoking-related cancers remained elevated throughout the entire follow-up period.

Conclusion: MI was associated with subsequent risk of cancer, driven by hematological, obesity- and smoking-related cancers in the short term and smoking-related cancers in the long term.

心肌梗死与后续癌症诊断的短期或长期风险:丹麦全国队列研究。
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来源期刊
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis 医学-外周血管病
CiteScore
24.30
自引率
3.80%
发文量
321
审稿时长
1 months
期刊介绍: The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.
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