Association Between Life's Essential 8 and Diabetic Kidney Disease in Patients With Diabetes Mellitus: Evidence From National Health and Nutrition Examination Survey 2005-2018

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-03-01 DOI:10.1016/j.eprac.2024.12.010

Yi Wei MD , Jiangyi Yu MD

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引用次数: 0

Abstract

Background

Diabetic kidney disease (DKD) is often connected with an elevated cardiovascular disease risk. A novel index, the Life's Essential 8 (LE8), was developed with the American Heart Association to ascertain cardiovascular health. In people with diabetes mellitus, we aimed to estimate if LE8 possessed a connection with DKD risk.

Methods

We implemented data from the National Health and Nutrition Examination Survey from 2005 to 2018. The correlation between LE8 and DKD was evaluated with weighted multivariate logistic regression models and restricted cubic spline models with covariate adjustments. In addition, we performed subgroup analyses and interaction tests.

Results

After taking into account relevant confounding factors, the findings indicated that higher levels of LE8 was linked to a decreased probability of developing DKD (per 10-point increase in LE8, OR = 0.75, 95%CI = 0.68-0.84, P < .001). The subscales of the LE8 similarly demonstrated negative associations with DKD risk. After grouping the LE8 scores, it was found that individuals with high LE8 were significantly less likely to develop DKD compared to those with low LE8 (OR = 0.32, 95%CI = 0.15-0.70, P = .005). The association between LE8 and DKD was consistent across different subgroups.

Conclusion

LE8 scores were shown to have a significantly negative association with the risk of DKD in people with diabetes mellitus. By concentrating on the state of cardiovascular health, it may be possible to lessen the impact of DKD.

查看原文本刊更多论文

糖尿病患者生命必需8与糖尿病肾病之间的关系：来自NHANES 2005-2018的证据

背景：糖尿病肾病（DKD）通常与心血管疾病风险升高有关。美国心脏协会（AHA）开发了一种新型指数--生命基本指数8（LE8），用于确定心血管健康状况。在糖尿病（DM）患者中，我们的目的是估计LE8是否与DKD风险有关：我们采用了 2005 年至 2018 年美国国家健康与营养调查（NHANES）的数据。通过加权多变量逻辑回归模型和带协变量调整的限制性立方样条（RCS）模型评估了LE8与DKD之间的相关性。此外，我们还进行了亚组分析和交互检验：结果：在考虑了相关混杂因素后，研究结果表明，LE8水平越高，患DKD的概率越低（LE8每增加10分，OR=0.75，95%CI=0.68-0.84，PC结论：LE8得分与糖尿病患者罹患DKD的风险呈显著负相关。通过关注心血管健康状况，或许可以减轻 DKD 的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.