ALKBH1: emerging biomarker and therapeutic target for cancer treatment.

IF 2.8 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Ming Zhu Xiao, Jin Yin Fu, Le Tao Bo, Yi Dong Li, Zhong Wei Lin, Zhe Sheng Chen
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引用次数: 0

Abstract

As neoplastic cells proliferate, disseminate, and infiltrate, they undergo substantial alterations in their epigenetic configuration. Among the pivotal enzymes implicated in this phenomenon is the AlkB family of demethylases, notably AlkB homolog 1 (ALKBH1), which demonstrates conspicuous upregulation across various malignancies. The heightened expression of ALKBH1 renders it a compelling candidate for the development of multifaceted anticancer modalities. Despite the commendable progress achieved by investigators in elucidating the perturbations associated with ALKBH1 in malignant tissues, a comprehensive mechanism remains elusive. The present study endeavors to address this lacuna by synthesizing recent advancements pertaining to ALKBH1's involvement in oncogenesis over the preceding decade. Therefore, this research not only furnishes novel insights but also establishes a foundation for prospective initiatives aimed at cancer prophylaxis and therapeutics that exploit epigenetic regulatory mechanisms.

ALKBH1:癌症治疗的新兴生物标志物和治疗靶点。
随着肿瘤细胞的增殖、扩散和浸润,它们的表观遗传结构发生了实质性的改变。与这一现象相关的关键酶是AlkB去甲基酶家族,特别是AlkB同源物1 (ALKBH1),它在各种恶性肿瘤中都表现出明显的上调。ALKBH1的高表达使其成为多方面抗癌模式发展的引人注目的候选者。尽管研究人员在阐明恶性组织中与ALKBH1相关的扰动方面取得了值得称赞的进展,但一个全面的机制仍然难以捉摸。本研究试图通过综合过去十年有关ALKBH1参与肿瘤发生的最新进展来解决这一空白。因此,这项研究不仅提供了新的见解,而且为利用表观遗传调控机制的癌症预防和治疗的前瞻性举措奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Discover. Oncology
Discover. Oncology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.40
自引率
9.10%
发文量
122
审稿时长
5 weeks
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