Palladium-Catalyzed Decarboxylative Domino Synthesis of Fused Quinolin-2(1H)-one Scaffolds Containing Perfluoroalkyl Unit

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-20 DOI:10.1039/d4qo01970a

Shuwei Li, Linqi Wang, Shangyuan Wang, Jun Ying

引用次数: 0

Abstract

A novel palladium-catalyzed domino radical cyclization and C-H activation/decarboxylation of 1,7-enynes with o-bromobenzoic acids and perfluoroalkyl iodides has been developed for the expedite construction of fused perfluoroalkyl-containing quinolin-2(1H)-one scaffolds. This method provides a facile synthesis of fused quinolin-2(1H)-one derivatives containing perfluoroalkyl unit in high yields. Notably, the late-stage modifications of various drugs were also demonstrated by using this method.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.