The impact of using cannabis during pregnancy on the infant and mother: An overview of systematic reviews, evidence map, targeted updates, and de novo synthesis

IF 1.4 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Australian & New Zealand Journal of Obstetrics & Gynaecology Pub Date : 2024-12-19 DOI:10.1111/ajo.13916

Zachary Munn, Danielle Pollock, Jennifer Stone, Sabira Hasanoff, Andrea Gordon, Carrie Price, Michael Stark, Timothy Hugh Barker

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Abstract

Background

Cannabis use during pregnancy is becoming more prevalent. While numerous studies have explored the relationship of cannabis use during pregnancy and outcomes for mothers and infants, uncertainty remains regarding the impact of cannabis use on pregnancy complications and later-life outcomes for offspring.

Aims

To produce a summary of the short and long-term effects of prenatal cannabis exposure on fetal growth and development, neonatal conditions, later-life, and maternal outcomes.

Materials and Methods

An overview of systematic reviews, an evidence and gap map, targeted updates of previous reviews, and de novo evidence synthesis was conducted. The databases searched include PubMed (National Center for Biotechnology Information); MEDLINE (Ovid); Embase (Ovid) and CINAHL with Full Text (EBSCO). Assessment of risk of bias was conducted in duplicate for all studies. Relevant studies were coded and are presented as an evidence and gap map. Where possible, meta-analyses were conducted with a narrative synthesis of the results. Primary studies and systematic reviews examining the relationship between cannabis consumption in pregnancy and the effect on fetal/child development, antenatal, and obstetric outcomes during pregnancy were eligible for inclusion.

Results

There were 89 studies/reviews eligible for inclusion in this review. There was a potentially harmful impact of prenatal cannabis exposure on all fetal growth and development outcomes, some neonatal outcomes, some later-life outcomes, and some maternal outcomes. The evidence regarding other neonatal conditions, later-life, and maternal outcomes was mixed.

Conclusions

The evidence suggests cannabis should be avoided during pregnancy.

Abstract Image

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怀孕期间使用大麻对母婴的影响：系统综述、证据图、有针对性的更新和从头合成。

背景：怀孕期间使用大麻越来越普遍。虽然许多研究探讨了怀孕期间使用大麻与母亲和婴儿结局的关系，但大麻使用对妊娠并发症和后代晚年结局的影响仍然不确定。目的：总结产前大麻暴露对胎儿生长发育、新生儿状况、后期生活和产妇结局的短期和长期影响。材料和方法：系统综述、证据和差距图、有针对性地更新以前的综述和从头证据合成。检索的数据库包括PubMed（国家生物技术信息中心）；MEDLINE(奥维德);Embase （Ovid）和CINAHL全文（EBSCO）。所有研究的偏倚风险评估均为一式两份。对相关研究进行编码，并作为证据和差距图呈现。在可能的情况下，采用叙述性综合结果进行meta分析。对怀孕期间吸食大麻与胎儿/儿童发育、产前和产科结局影响之间关系的初步研究和系统评价符合纳入条件。结果：有89项研究/综述符合纳入本综述的条件。产前接触大麻对所有胎儿生长发育结果、一些新生儿结果、一些晚年结果和一些产妇结果都有潜在的有害影响。关于其他新生儿状况、晚年生活和产妇结局的证据是混合的。结论：有证据表明怀孕期间应避免使用大麻。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian & New Zealand Journal of Obstetrics & Gynaecology 医学-妇产科学

CiteScore

3.40

自引率

11.80%

发文量

165

审稿时长

4-8 weeks

期刊介绍： The Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG) is an editorially independent publication owned by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) and the RANZCOG Research foundation. ANZJOG aims to provide a medium for the publication of original contributions to clinical practice and/or research in all fields of obstetrics and gynaecology and related disciplines. Articles are peer reviewed by clinicians or researchers expert in the field of the submitted work. From time to time the journal will also publish printed abstracts from the RANZCOG Annual Scientific Meeting and meetings of relevant special interest groups, where the accepted abstracts have undergone the journals peer review acceptance process.