Microbiome Differences in Colorectal Cancer Patients and Healthy Individuals: Implications for Vaccine Antigen Discovery.

IF 6.2 Q1 IMMUNOLOGY
ImmunoTargets and Therapy Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI:10.2147/ITT.S486731
Gordon C Ibeanu, Adekunle B Rowaiye, Joy C Okoli, Daniel U Eze
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引用次数: 0

Abstract

Background: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, with numerous risk factors contributing to its development. Recent research has illuminated the significant role of the gut microbiota in CRC pathogenesis, identifying various microbial antigens as potential targets for vaccine development.

Aim: This review aimed at exploring the potential sources of microbial antigens that could be harnessed to create effective CRC vaccines and understand the role of microbiome-CRC interactions in carcinogenesis.

Methods: A comprehensive search of original research and review articles on the pathological links between key microbial candidates, particularly those more prevalent in CRC tissues, was conducted. This involved extensive use of the PubMed and Medline databases, as well as the Google Scholar search engine, utilizing pertinent keywords. A total of one hundred and forty-three relevant articles in English, mostly published between 2018 and 2024, were selected.

Results: Numerous microbes, particularly bacteria and viruses, are significantly overrepresented in CRC tissues and have been shown to promote tumorigenesis by inducing inflammation and modulating the immune system. This makes them promising candidates for antigens in the development of CRC vaccines.

Conclusion: The selection of microbial antigens focuses on their capacity to trigger a strong immune response and their link to tumor presence and progression. Identifying and validating these antigens through preclinical testing is essential in developing a CRC vaccine.

结直肠癌患者和健康个体的微生物组差异:疫苗抗原发现的意义
背景:结直肠癌(CRC)是世界上第三大最常见的癌症,有许多危险因素导致其发展。最近的研究已经阐明了肠道微生物群在结直肠癌发病机制中的重要作用,确定了各种微生物抗原作为疫苗开发的潜在靶点。目的:本综述旨在探索微生物抗原的潜在来源,以开发有效的结直肠癌疫苗,并了解微生物组-结直肠癌相互作用在癌变中的作用。方法:全面检索关键候选微生物之间病理联系的原始研究和综述文章,特别是那些在结直肠癌组织中更普遍的微生物。这涉及广泛使用PubMed和Medline数据库,以及谷歌学者搜索引擎,利用相关关键词。共有143篇相关英文文章入选,这些文章大多发表于2018年至2024年之间。结果:许多微生物,特别是细菌和病毒,在结直肠癌组织中显著过量,并已被证明通过诱导炎症和调节免疫系统来促进肿瘤发生。这使得它们在CRC疫苗开发中成为有希望的抗原候选物。结论:微生物抗原的选择侧重于其触发强烈免疫反应的能力及其与肿瘤存在和进展的联系。通过临床前测试识别和验证这些抗原对于开发结直肠癌疫苗至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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