İbrahim Acır, Hacı Ali Erdoğan, Ertuğrul Toka, Vildan Yayla
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引用次数: 0
Abstract
Background: The aim of this study is to examine the hematological and biochemical variables in patients diagnosed with cancer-related stroke who have different types of cancer and to evaluate the effects of these variables.
Methods: This retrospective study was conducted at a tertiary hospital stroke center and included 153 patients diagnosed with cancer-related stroke. Comprehensive etiological investigations were performed, and patients were classified according to the Trial of Org 101072 in Acute Stroke Treatment (TOAST) classification. Laboratory parameters including d-dimer, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen levels were collected from blood samples taken at the time of stroke. Statistical analysis was performed using 1-way analysis of variance to assess differences in laboratory parameters across different cancer types.
Results: The study found significant variations in hematological and biochemical parameters among different cancer types. Specifically, glomerular filtration rate, activated partial thromboplastin time, prothrombin time, and international normalized ratio levels showed significant differences across cancer types (P < 0.05), indicating that these factors may play distinct roles in the pathophysiology of cancer-related strokes. d-dimer, CRP, and sedimentation levels were significantly elevated in certain cancer types such as rectal, endometrial, and pancreatic cancers (P < .01). These findings suggest a strong association between hypercoagulability and increased risk of stroke in these patients.
Conclusions: This retrospective study highlights the importance of considering cancer-specific factors in the management of stroke risk, particularly in cancers such as pancreatic and colon, which show a predisposition to earlier stroke occurrence. The elevated coagulation factors in these patients suggest the potential need for early preventive treatment with anticoagulants or thrombin inhibitors.
背景：本研究的目的是检查诊断为癌症相关脑卒中的不同类型癌症患者的血液学和生化变量，并评估这些变量的影响。方法：本回顾性研究在一家三级医院卒中中心进行，纳入153例诊断为癌症相关卒中的患者。进行全面的病因调查，并根据急性卒中治疗（TOAST）的临床试验（Trial of Org 101072）对患者进行分类。实验参数包括d-二聚体、c反应蛋白（CRP）、红细胞沉降率（ESR）和纤维蛋白原水平。采用单向方差分析进行统计分析，以评估不同癌症类型间实验室参数的差异。结果：研究发现不同癌症类型的血液学和生化指标存在显著差异。具体来说，肾小球滤过率、活化的部分凝血活酶时间、凝血酶原时间和国际标准化比率水平在不同癌症类型中显示出显著差异(P P结论：本回顾性研究强调了在卒中风险管理中考虑癌症特异性因素的重要性，特别是在胰腺癌和结肠癌等癌症中，这些癌症显示出早期卒中发生的倾向。这些患者的凝血因子升高提示可能需要使用抗凝剂或凝血酶抑制剂进行早期预防性治疗。
期刊介绍：
Clinical Medicine Insights: Oncology is an international, peer-reviewed, open access journal that focuses on all aspects of cancer research and treatment, in addition to related genetic, pathophysiological and epidemiological topics. Of particular but not exclusive importance are molecular biology, clinical interventions, controlled trials, therapeutics, pharmacology and drug delivery, and techniques of cancer surgery. The journal welcomes unsolicited article proposals.
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