Astrid Most, Vincent Groesser, Sophie Hoelscher, Rebecca Weber, Ebru Akdogan-Gernandt, Lutz Kraushaar, Oliver Dörr, Jamschid Sedighi, Stanislav Keranov, Faeq Husain-Syed, Christian W Hamm, Samuel Sossalla, Pascal Bauer
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引用次数: 0
Abstract
Background: The systolic blood pressure/workload (SBP/MET) slope was recently reported to reliably identify an exaggerated blood pressure response (eBPR) in the normal population and in athletes. We investigated whether the aortic root diameter (AoD) also correlates with an eBPR and vascular function in elite athletes.
Methods: We examined 652 healthy male elite athletes (age 25.8 ± 5 years) of mixed sports with a standardized maximum exercise test. Central blood pressure and vascular function were measured non-invasively with a validated oscillometric device. The SBP/MET slope was calculated and the threshold for an eBPR was set at > 6.2 mmHg/MET. Two groups were defined (≤ 6.2 and > 6.2 mmHg/MET), and an association between AoD and vascular function with the SBP/MET slope was evaluated for each group.
Results: Athletes with an eBPR (n = 191, 29%) displayed a higher systolic central BP (103 ± 7.7 vs. 101 ± 9.2 mmHg, p = 0.004), larger AoD (32.8 ± 3.3 vs. 31.9. ± 3.2 mm, p < 0.001), a higher AoD/left ventricular end-diastolic diameter (LVEDD) ratio (0.62 ± 0.061 vs. 0.59. ± 0.056, p < 0.001), a lower LVEDD/AoD ratio (1.64 ± 0.16 vs. 1.69. ± 0.16, p < 0.001), and a lower absolute (299 ± 59 vs. 379 ± 65 W, p < 0.001) and relative workload (3.17 ± 0.55 vs. 4.05 ± 1.2 W/kg, p < 0.001) vs. athletes with a normal SBP/MET slope (n = 461, 71%). No differences between the two groups were found after indexing AoD to body surface area (BSA) (14.76 ± 1.36 vs. 14.73 ± 1.41, p = 0.772).
Conclusion: Athletes with eBPR displayed altered AoD/LVEDD and LVEDD/AoD ratios, whereas AoD/BSA indexing was not different. Further longitudinal studies are encouraged to explore these metrics and their role in aortic remodeling of athletes.
背景：最近有报道称收缩压/负荷（SBP/MET）斜率可以可靠地识别正常人群和运动员的过度血压反应（eBPR）。我们研究了优秀运动员的主动脉根直径（AoD）是否也与eBPR和血管功能相关。方法：对652名健康男性优秀混合运动运动员（25.8±5岁）进行标准化最大运动测试。中心血压和血管功能用一种经过验证的示波仪进行无创测量。计算了SBP/MET斜率，并将eBPR阈值设置为> 6.2 mmHg/MET。定义两组（≤6.2和> 6.2 mmHg/MET），并评估AoD和血管功能与收缩压/MET斜率之间的关系。结果：eBPR运动员（n = 191, 29%）心脏收缩压较高（103±7.7 vs. 101±9.2 mmHg, p = 0.004）， AoD较大（32.8±3.3 vs. 31.9±3.2 mm, p）。结论：eBPR运动员AoD/LVEDD和LVEDD/AoD比值改变，AoD/BSA指数无差异。鼓励进一步的纵向研究来探索这些指标及其在运动员主动脉重塑中的作用。
期刊介绍：
Clinical Research in Cardiology is an international journal for clinical cardiovascular research. It provides a forum for original and review articles as well as critical perspective articles. Articles are only accepted if they meet stringent scientific standards and have undergone peer review. The journal regularly receives articles from the field of clinical cardiology, angiology, as well as heart and vascular surgery.
As the official journal of the German Cardiac Society, it gives a current and competent survey on the diagnosis and therapy of heart and vascular diseases.
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