Development of Behçet's disease on maintenance therapy for autoimmune hepatitis.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
George Thieroff, Samantha Jane Bartholow, Adam Kilian
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引用次数: 0

Abstract

Behçet's disease is a clinical diagnosis with variable presentations. Liver involvement is rare in the absence of vascular complications. We describe a patient diagnosed with Hashimoto's thyroiditis and autoimmune hepatitis on azathioprine who developed extensive aphthous ulcers approximately 10 years later. She was initially diagnosed with an overlap autoimmune connective tissue disorder in the setting of a positive anti-Ro antibody. Symptoms did not resolve with prednisone, hydroxychloroquine or mycophenolate mofetil. She subsequently developed pseudofolliculitis, erythema nodosum-like lesions, large cutaneous ulcers and pathergy phenomenon at sites of venipuncture consistent with Behçet's disease. She was successfully treated with infliximab, azathioprine, colchicine and apremilast. This case represents an unusual sequence of autoimmune conditions and a diagnostic challenge.

自身免疫性肝炎维持治疗中behaperet病的进展
behaperet病是一种临床诊断,表现多样。在没有血管并发症的情况下,肝脏受累是罕见的。我们描述了一个病人诊断为桥本甲状腺炎和自身免疫性肝炎的硫唑嘌呤谁发展广泛的阿弗顿溃疡大约10年后。在抗ro抗体阳性的情况下,她最初被诊断为重叠自身免疫性结缔组织疾病。强的松、羟氯喹或霉酚酸酯不能缓解症状。随后她出现假性毛囊炎、结节样红斑病变、大面积皮肤溃疡和静脉穿刺处病变现象,与behaperet病一致。她成功地用英夫利昔单抗、硫唑嘌呤、秋水仙碱和阿普雷米司特治疗。本病例代表了一系列不寻常的自身免疫性疾病和诊断挑战。
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来源期刊
BMJ Case Reports
BMJ Case Reports Medicine-Medicine (all)
CiteScore
1.40
自引率
0.00%
发文量
1588
期刊介绍: BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.
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