Aging2Cancer: an integrated resource for linking aging to tumor multi-omics data.

IF 3.5 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

BMC Genomics Pub Date : 2024-12-18 DOI:10.1186/s12864-024-11150-z

Dahua Xu, Yutong Shen, Nihui Zhang, Guoqing Deng, Dehua Zheng, Peihu Li, Jiale Cai, Guanghui Tian, Qingchen Wei, Hongyan Jiang, Jiankai Xu, Bo Wang, Kongning Li

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引用次数: 0

Abstract

Background: Aging and tumorigenesis share intricate regulatory processes, that alter the genome, epigenome, transcriptome and immune landscape of tissues. Discovering the link between aging and cancer in terms of multiomics characteristics remains a challenge for biomedical researchers.

Methods: We collected high-throughput datasets for 57 human tumors and 20 normal tissues, including 23,125 samples with age information. On the basis of these sufficient omics data, we introduced six useful modules including genomic (somatic mutation and copy number variation), gene expression, DNA methylation, hallmarks (aging and cancer), immune landscape (immune infiltration, immune pathways, immune signatures, and antitumor immune activities) and survival analysis. Correlation and differential analyses were performed for the multiomic signatures associated with aging at the gene level.

Results: We developed Aging2Cancer ( http://210.37.77.200:8080/Aging2Cancer/index.jsp ), which is a comprehensive database and analysis platform for revealing the associations between aging and cancer. Users can search for and visualize the results of genes of interest to explore the relationships between aging and cancer at the gene level for different omics levels.

Conclusions: We believe that Aging2Cancer is a valuable resource for identifying novel biomarkers and will serve as a bridge for linking aging to cancer.

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Aging2Cancer：连接衰老与肿瘤多组学数据的集成资源。

背景：衰老和肿瘤发生共享复杂的调控过程，改变组织的基因组、表观基因组、转录组和免疫景观。在多组学特征方面发现衰老和癌症之间的联系仍然是生物医学研究人员面临的一个挑战。方法：我们收集了57例人类肿瘤和20例正常组织的高通量数据集，包括23125例具有年龄信息的样本。在这些足够的组学数据的基础上，我们引入了6个有用的模块，包括基因组（体细胞突变和拷贝数变异）、基因表达、DNA甲基化、特征（衰老和癌症）、免疫景观（免疫浸润、免疫途径、免疫特征和抗肿瘤免疫活性）和生存分析。在基因水平上对与衰老相关的多组学特征进行相关性和差异性分析。结果：我们开发了Aging2Cancer (http://210.37.77.200:8080/Aging2Cancer/index.jsp)，这是一个揭示衰老与癌症之间关系的综合数据库和分析平台。用户可以搜索并可视化感兴趣的基因结果，在不同组学水平上探索基因水平上衰老与癌症之间的关系。结论：我们相信Aging2Cancer是鉴定新型生物标志物的宝贵资源，将成为连接衰老与癌症的桥梁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Genomics 生物-生物工程与应用微生物

CiteScore

7.40

自引率

4.50%

发文量

769

审稿时长

6.4 months

期刊介绍： BMC Genomics is an open access, peer-reviewed journal that considers articles on all aspects of genome-scale analysis, functional genomics, and proteomics. BMC Genomics is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.