Rising mortality rates linked to type-2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-12-19 DOI:10.1111/jdi.14386

Mushood Ahmed, Abdullah Nofal, Aimen Shafiq, Hira Javaid, Areeba Ahsan, Zain Ali Nadeem, Raheel Ahmed, Mahboob Alam, Mamas A Mamas, Marat Fudim, Gregg C Fonarow

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引用次数: 0

Abstract

Background: The prevalence of type 2 diabetes (T2D) and obesity are increasing in the United States. However, population-level data for mortality trends due to T2D and obesity are limited. This study aims to assess these death trends among adults in the United States categorized by sex, race, and geographical location.

Methods: We queried the CDC-WONDER database for multiple cause of death data of adults aged ≥25 years. The crude mortality rates (CMR), age-adjusted mortality rates (AAMRs), annual percent change (APC), and the average APC (AAPC) along with a 95% confidence interval (CI) were analyzed.

Results: From 1999 to 2022, a total of 88,597 T2DM and obesity-related deaths were recorded in the United States. The AAMR consistently increased from 1999 to 2017 (APC: 7.64; 95% CI: 1.91-9.96), followed by a marked rise from 2017 to 2022 (APC: 20.13; 95% CI: 12.88-38.57). The AAMR was approximately 3.58 times higher during the COVID-19 pandemic compared to the period from 1999 to 2019. The AAMR for males was consistently greater than that for females. The highest AAMR was observed in non-Hispanic (NH) Blacks or African Americans, followed by NH White, Hispanic or Latino, and other NH populations. Rural areas (AAMR: 1.86, 95% CI: 1.83-1.89) exhibited a greater AAMR than urban regions 1.26 (95% CI: 1.25-1.27).

Conclusions: Our results indicate a substantial increasing trend of T2D and obesity-related deaths in the United States especially during the COVID-19 pandemic.

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美国与2型糖尿病和肥胖相关的死亡率上升：1999年至2022年的观察性分析

背景：在美国，2型糖尿病（T2D）和肥胖症的患病率正在上升。然而，关于t2dm和肥胖导致的死亡率趋势的人口水平数据有限。本研究旨在评估按性别、种族和地理位置分类的美国成年人的这些死亡趋势。方法：通过CDC-WONDER数据库查询年龄≥25岁成人的多死因死亡数据。分析粗死亡率（CMR）、年龄调整死亡率（AAMRs）、年变化百分比（APC）和平均APC （AAPC）以及95%可信区间（CI）。结果：从1999年到2022年，美国共记录了88,597例T2DM和肥胖相关死亡。1999 - 2017年AAMR持续上升(APC: 7.64；95% CI: 1.91-9.96)，随后从2017年到2022年显著上升(APC: 20.13；95% ci: 12.88-38.57)。在2019冠状病毒病大流行期间，AAMR比1999年至2019年期间高出约3.58倍。男性的AAMR始终大于女性。AAMR在非西班牙裔（NH）黑人或非裔美国人中最高，其次是NH白人、西班牙裔或拉丁裔和其他NH人群。农村地区（AAMR: 1.86, 95% CI: 1.83-1.89）的AAMR高于城市地区（1.26,95% CI: 1.25-1.27）。结论：我们的研究结果表明，在美国，尤其是在COVID-19大流行期间，T2D和肥胖相关的死亡人数呈大幅增加趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).