Assessment of Relationship Between Dietary Factors, Socioeconomic Factors, Behavioral Factors, Physical Measurement, and Risk of Migraine: A Univariable and Multivariable Mendelian Randomization Study.

IF 3.1 3区 医学 Q2 ANESTHESIOLOGY
Yanhua Zhang, Hongwei Liu, Xuan Chen, Defu Dong
{"title":"Assessment of Relationship Between Dietary Factors, Socioeconomic Factors, Behavioral Factors, Physical Measurement, and Risk of Migraine: A Univariable and Multivariable Mendelian Randomization Study.","authors":"Yanhua Zhang, Hongwei Liu, Xuan Chen, Defu Dong","doi":"10.1097/AJP.0000000000001268","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Although numerous studies have identified associations between socioeconomic, behavioral, dietary, and physical factors and migraine, the causal nature of these relationships has yet to be adequately established.</p><p><strong>Materials and methods: </strong>We utilized 2-sample Mendelian randomization (MR) to elucidate the causal associations of 28 distinct traits for socioeconomic factors, behavioral factors, dietary factors, and physical measurement with migraine. In the univariable MR analysis, the inverse-variance weighted method served as the primary analytic approach. Robustness checks included the Cochran Q test, Egger intercept test, and leave-one-out analysis. A multivariable MR analysis framework was utilized to assess the direct causal impacts of these traits on migraine risk.</p><p><strong>Results: </strong>The univariable MR analysis analysis revealed that genetic predispositions to higher coffee intake (Odds Ratio (OR) = 0.547; 95% CI = 0.359-0.834; P = 0.005), greater oily fish intake (OR = 0.556; 95% CI = 0.394-0.785; P = 0.001), and higher educational attainment (OR = 0.916; 95% CI = 0.884-0.949; P < 0.001) were associated with reduced migraine risk. In contrast, predispositions to higher poultry intake (OR = 4.690; 95% CI = 1.377-15.977; P = 0.013) and longer mobile phone use (OR = 1.526; 95% CI = 1.080-2.157; P = 0.017) correlated with increased risk. These associations remained consistent in the multivariable MR analysis after adjusting for stroke and particulate matter air pollution.</p><p><strong>Conclusions: </strong>Our study robustly supports the significant causal roles of specific socioeconomic, behavioral, and dietary factors with physical measurement in the development of migraine. Notably, coffee intake, oily fish intake, and educational attainment appear protective, whereas poultry intake and extensive mobile phone use elevate risk. These insights pave the way for developing targeted preventive strategies for migraine.</p>","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Journal of Pain","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/AJP.0000000000001268","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Although numerous studies have identified associations between socioeconomic, behavioral, dietary, and physical factors and migraine, the causal nature of these relationships has yet to be adequately established.

Materials and methods: We utilized 2-sample Mendelian randomization (MR) to elucidate the causal associations of 28 distinct traits for socioeconomic factors, behavioral factors, dietary factors, and physical measurement with migraine. In the univariable MR analysis, the inverse-variance weighted method served as the primary analytic approach. Robustness checks included the Cochran Q test, Egger intercept test, and leave-one-out analysis. A multivariable MR analysis framework was utilized to assess the direct causal impacts of these traits on migraine risk.

Results: The univariable MR analysis analysis revealed that genetic predispositions to higher coffee intake (Odds Ratio (OR) = 0.547; 95% CI = 0.359-0.834; P = 0.005), greater oily fish intake (OR = 0.556; 95% CI = 0.394-0.785; P = 0.001), and higher educational attainment (OR = 0.916; 95% CI = 0.884-0.949; P < 0.001) were associated with reduced migraine risk. In contrast, predispositions to higher poultry intake (OR = 4.690; 95% CI = 1.377-15.977; P = 0.013) and longer mobile phone use (OR = 1.526; 95% CI = 1.080-2.157; P = 0.017) correlated with increased risk. These associations remained consistent in the multivariable MR analysis after adjusting for stroke and particulate matter air pollution.

Conclusions: Our study robustly supports the significant causal roles of specific socioeconomic, behavioral, and dietary factors with physical measurement in the development of migraine. Notably, coffee intake, oily fish intake, and educational attainment appear protective, whereas poultry intake and extensive mobile phone use elevate risk. These insights pave the way for developing targeted preventive strategies for migraine.

饮食因素、社会经济因素、行为因素、身体测量与偏头痛风险之间关系的评估:单变量和多变量孟德尔随机研究》。
目的:尽管许多研究已经确定了社会经济、行为、饮食和身体因素与偏头痛之间的联系,但这些关系的因果性质尚未得到充分确立。方法:采用双样本孟德尔随机化方法,分析社会经济因素、行为因素、饮食因素和体格测量等28个不同特征与偏头痛的因果关系。在单变量孟德尔随机化分析中,反方差加权法是主要的分析方法。稳健性检验包括Cochran Q检验、Egger截距检验和留一分析。使用多变量孟德尔随机化分析框架来评估这些特征对偏头痛风险的直接因果影响。结果:单变量孟德尔随机化分析显示,高咖啡摄入量的遗传倾向(OR=0.547;95%可信区间= 0.359 - -0.834;P=0.005),摄入更多的油性鱼类(OR=0.556;95%可信区间= 0.394 - -0.785;P=0.001),较高的受教育程度(OR=0.916;95%可信区间= 0.884 - -0.949;结论:我们的研究有力地支持了特定的社会经济、行为和饮食因素与身体测量在偏头痛发展中的重要因果作用。值得注意的是,咖啡摄入量、油性鱼类摄入量和受教育程度似乎具有保护作用,而家禽摄入量和广泛使用手机则会增加风险。这些见解为制定有针对性的偏头痛预防策略铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Clinical Journal of Pain
Clinical Journal of Pain 医学-临床神经学
CiteScore
5.40
自引率
3.40%
发文量
118
审稿时长
4-8 weeks
期刊介绍: ​​​The Clinical Journal of Pain explores all aspects of pain and its effective treatment, bringing readers the insights of leading anesthesiologists, surgeons, internists, neurologists, orthopedists, psychiatrists and psychologists, clinical pharmacologists, and rehabilitation medicine specialists. This peer-reviewed journal presents timely and thought-provoking articles on clinical dilemmas in pain management; valuable diagnostic procedures; promising new pharmacological, surgical, and other therapeutic modalities; psychosocial dimensions of pain; and ethical issues of concern to all medical professionals. The journal also publishes Special Topic issues on subjects of particular relevance to the practice of pain medicine.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信