Anatomy-based diffusion-weighted MRI quality metric: a proof-of-concept for deriving accurate muscle fiber orientation.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Nadya Shusharina, Evangelia Kaza, Miranda B Lam, Stephan E Maier
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引用次数: 0

Abstract

Objective.Diffusion-weighted MRI (DW-MRI) is used to quantitatively characterize the microscopic structure of muscle through anisotropic water diffusion in soft tissue. Applications such as tumor propagation modeling require precise detection of muscle fiber orientation. That is, the direction along the fibers that coincides with the direction of the principal eigenvector of the diffusion tensor reconstructed from DW-MRI data. For clinical applications, the quality of image data is determined by the signal-to-noise ratio (SNR) that must be achieved within the appropriate scan time. The acquisition protocol must therefore be optimized. This implies the need for SNR criteria that match the data quality of the application.Approach.Muscles with known structural heterogeneity, e.g. bipennate muscles such as the rectus femoris in the thigh, provide a natural quality benchmark to determine accuracy of inferred fiber orientation at different scan parameters. In this study, we analyze DW-MR images of the thigh of a healthy volunteer at different SNRs and use PCA to identify subsets of voxels with different directions of diffusion tensor eigenvectors corresponding to different pennate angles. We propose to use the separation index of spatial co-localization of the clustered eigenvectors as a quality metric for fiber orientation detection.Main results.The clustering in the PCA component coordinates can be translated to the separation of the two compartments of the bipennate muscle on either side of the central tendon according to the pennate angle. The separation index reflects the degree of the separation and is a function of SNR.Significance.Because the separation index allows joint estimation of spatial and directional noise in DW-MRI as a single parameter, it will allow future quantitative optimization of DW-MRI soft tissue protocols.

基于解剖的弥散加权MRI质量度量:一种概念验证,用于获得准确的肌纤维方向。
目的:利用扩散加权MRI (diffusion weighted MRI, DW-MRI)技术,通过软组织中水分的各向异性扩散,定量表征肌肉的微观结构。肿瘤传播建模等应用需要精确检测肌纤维方向。也就是说,沿着纤维的方向与从DW-MRI数据重建的扩散张量的主特征向量的方向一致。对于临床应用,图像数据的质量取决于在适当的扫描时间内必须达到的信噪比(SNR)。因此,必须对采集协议进行优化。这意味着需要匹配应用程序数据质量的信噪比标准。& # xD;方法。已知结构不均匀的肌肉,如双足肌,如大腿的股直肌,提供了一个自然的质量基准,以确定在不同扫描参数下推断纤维方向的准确性。在本研究中,我们分析了健康志愿者在不同信噪比下的大腿DW-MR图像,并使用PCA识别不同方向的扩散张量特征向量对应不同的pennate角度的体素子集。我们建议使用聚类特征向量的空间共定位分离指标作为纤维方向检测的质量度量。 ;PCA分量坐标中的聚类可以翻译为中央肌腱两侧双足肌的两个隔室根据矢状角的分离。分离指数反映分离程度,是信噪比的函数。& # xD;意义。由于分离指数可以将DW-MRI中的空间和方向噪声作为单个参数进行联合估计,因此它将允许未来对DW-MRI软组织方案进行定量优化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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