The challenge of exploring neuropsychiatric and cognitive symptoms after spontaneous intracerebral hemorrhage

IF 4.5 2区 医学 Q1 CLINICAL NEUROLOGY
Giuseppe Scopelliti, Charlotte Cordonnier, Leonardo Pantoni
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Nevertheless, we might hypothesize that those patients suffering from lower levels of disability after the index event are probably the ones who are going to benefit the most from a long-term stroke neuropsychiatric and cognitive follow-up.</p><p>Given that most studies have predominantly focused on small ICHs, our understanding of the cognitive and neuropsychiatric consequences of ICH survivors so far may reflect more the influence of the underlying cerebral small vessel disease (e.g., arteriolosclerosis and cerebral amyloid angiopathy) rather than the direct impact of the initial ICH event. Although this study did not assess MRI features of cerebral small vessel disease, the authors found that potentially modifiable factors related to ICH at baseline (e.g., blood pressure levels, length of hospitalization, and anteroposterior diameter of the index ICH) could influence long-term cognitive and affective outcomes. 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引用次数: 0

Abstract

Spontaneous intracerebral hemorrhage (ICH) is an extremely dangerous condition, with overall greater social-economic burden than ischemic stroke despite lower incidence. Approximately half of patients with acute ICH do not survive beyond the first year, and those who do often face significant, lasting disability [1]. Qiuyi Jiang et al. investigated one of the more subtle long-term effects of ICH, the affective and cognitive symptoms that have been often overlooked by stroke neurologists, but are an especially pressing burden for patients and their caregivers [2, 3]. This study, conducted in China, included nearly 1600 patients, marking the largest cohort on this topic to date. However, the majority of participants had deep ICH (85%) and were relatively young (median age 57 years), limiting the generalizability of the findings to older populations with lobar ICH.

Although the study explicitly focused on “small” ICHs (median volume of 10 mL), it should be noted that the majority of previous studies on long-term cognitive and neuropsychiatric outcomes of ICH have also predominantly included patients with smaller hematoma volumes [4, 5]. This is mainly because larger hemorrhages are associated with poor short-term survival, or patients are less likely to be able to attend outpatient clinic for long term follow-up. Similar considerations can be made regarding studies on the long-term cognitive consequences of ischemic stroke, in which patients with more severe events and language impairment are often excluded, resulting in an unavoidable bias in evaluating long-term trajectories [6]. Nevertheless, we might hypothesize that those patients suffering from lower levels of disability after the index event are probably the ones who are going to benefit the most from a long-term stroke neuropsychiatric and cognitive follow-up.

Given that most studies have predominantly focused on small ICHs, our understanding of the cognitive and neuropsychiatric consequences of ICH survivors so far may reflect more the influence of the underlying cerebral small vessel disease (e.g., arteriolosclerosis and cerebral amyloid angiopathy) rather than the direct impact of the initial ICH event. Although this study did not assess MRI features of cerebral small vessel disease, the authors found that potentially modifiable factors related to ICH at baseline (e.g., blood pressure levels, length of hospitalization, and anteroposterior diameter of the index ICH) could influence long-term cognitive and affective outcomes. This finding underscores the importance of consistently including cognitive and affective measures as outcome variables in clinical trials of acute phase interventions.

Another important catch on the current topic is the complex presentation of affective symptoms following an ICH, and, more broadly, in patients with cerebrovascular diseases. Qiuyi Jiang and colleagues adopted a pragmatic approach, using both in-hospital and telephone-based assessments to evaluate patients' cognitive and affective status. While this method may boost neuropsychiatric screening rates, categorizing a patient as simply having depressive or anxiety symptoms may not capture the full complexity of the neuropsychiatric profile, especially as growing evidence shows that different mood and cognitive manifestations are often interlinked and comorbid. We now recognize that the neuropsychiatric profile may reflect both the structural integrity and age-related changes of the brain (e.g., neurodegeneration, vascular burden), offering insights into the cognitive status of patients with stroke [5, 7]. This understanding is especially important when evaluating post-ICH depression, as different neuropsychiatric patterns may be present under the general category of depressive symptoms; for example, identifying apathetic traits alongside mood disturbances could help to pinpoint the patients at greater risk for cognitive impairment [8]. The tools currently used in clinical practice do not adequately capture the nuanced neuropsychiatric status of cerebrovascular patients: developing new, multidimensional screening instruments to better assess this complexity remains a significant challenge for the future.

Giuseppe Scopelliti: Conceptualization; writing – original draft. Charlotte Cordonnier: Writing – review and editing; conceptualization. Leonardo Pantoni: Writing – review and editing; conceptualization.

None.

探索自发性脑出血后神经精神和认知症状的挑战。
自发性脑出血(ICH)是一种极其危险的疾病,尽管发病率较低,但总体上比缺血性中风具有更大的社会经济负担。大约一半的急性脑出血患者无法存活超过第一年,而那些存活的患者往往面临严重的、持久的残疾风险。Qiuyi Jiang等人研究了脑出血的一个更微妙的长期影响,即中风神经科医生经常忽视的情感和认知症状,但这对患者及其护理人员来说是一个特别紧迫的负担[2,3]。该研究在中国进行,包括近1600名患者,是迄今为止该主题最大的队列研究。然而,大多数参与者患有深部脑出血(85%)并且相对年轻(中位年龄57岁),限制了研究结果在老年脑叶性脑出血人群中的普遍性。虽然该研究明确关注“小”脑出血(中位容量为10 mL),但应该注意的是,之前大多数关于脑出血长期认知和神经精神预后的研究也主要包括血肿体积较小的患者[4,5]。这主要是因为较大的出血与较差的短期生存有关,或者患者不太可能参加门诊进行长期随访。对于缺血性脑卒中的长期认知后果的研究也可以有类似的考虑,其中往往排除了事件更严重和语言障碍的患者,导致在评估长期轨迹时不可避免地存在偏差[10]。然而,我们可以假设,那些在指数事件后残疾程度较低的患者可能是那些将从长期中风神经精神和认知随访中获益最多的人。鉴于大多数研究主要集中在小脑出血上,我们对脑出血幸存者的认知和神经精神后果的理解到目前为止可能更多地反映了潜在的脑血管疾病(例如,小动脉硬化和脑淀粉样血管病)的影响,而不是初始脑出血事件的直接影响。虽然这项研究没有评估脑血管疾病的MRI特征,但作者发现,基线时与脑出血相关的潜在可改变因素(如血压水平、住院时间和脑出血指数的前后径)可能影响长期认知和情感结果。这一发现强调了在急性期干预的临床试验中始终如一地将认知和情感测量作为结果变量的重要性。当前主题的另一个重要问题是脑出血后情感症状的复杂表现,更广泛地说,在脑血管疾病患者中。蒋秋怡及其同事采用了务实的方法,使用住院和电话评估来评估患者的认知和情感状态。虽然这种方法可能会提高神经精神病学的筛查率,但将患者简单地归类为抑郁或焦虑症状可能无法捕捉到神经精神病学特征的全部复杂性,特别是越来越多的证据表明,不同的情绪和认知表现通常是相互关联的,并且是共病的。我们现在认识到,神经精神病学特征可以反映大脑的结构完整性和与年龄相关的变化(例如,神经变性,血管负担),为中风患者的认知状态提供了见解[5,7]。在评估脑出血后抑郁症时,这种理解尤为重要,因为在抑郁症状的一般类别下可能存在不同的神经精神模式;例如,识别情绪障碍和冷漠特征可以帮助确定认知障碍风险更高的患者。目前在临床实践中使用的工具并不能充分捕捉脑血管患者细致入微的神经精神状态:开发新的、多维的筛查工具来更好地评估这种复杂性仍然是未来的一个重大挑战。Giuseppe Scopelliti:概念化;写作-原稿。Charlotte Cordonnier:写作-评论和编辑;概念化。列奥纳多·潘东尼:写作——评论和编辑;conceptualization.None。
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来源期刊
European Journal of Neurology
European Journal of Neurology 医学-临床神经学
CiteScore
9.70
自引率
2.00%
发文量
418
审稿时长
1 months
期刊介绍: The European Journal of Neurology is the official journal of the European Academy of Neurology and covers all areas of clinical and basic research in neurology, including pre-clinical research of immediate translational value for new potential treatments. Emphasis is placed on major diseases of large clinical and socio-economic importance (dementia, stroke, epilepsy, headache, multiple sclerosis, movement disorders, and infectious diseases).
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