Reduction of nicotine content in tobacco through microbial degradation: research progress and potential applications

IF 6.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology for Biofuels Pub Date : 2024-12-18 DOI:10.1186/s13068-024-02593-3

Zi-Jia Li, Dong-Dong Yang, Zhi-Yun Wei, Jie Huang, Yi-Qian Chi, You-Xuan Lu, Feng-Wei Yin

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Abstract

Originally native to South America, tobacco and is now distributed worldwide as a major cash crop. Nicotine is the main harmful component of tobacco leaves, cigarette smoke and tobacco waste, which severely affects not only the flavor of the tobacco leaf, but also causes great damage to human health. As the anti-smoking movement continued to grow since the 1950s, and consumers become more aware of their health and environmental protection, the world tobacco industry has been committed to research, develop and produce low nicotine cigarette products with relatively low risk to human health. Among various approaches, the use of microorganisms to reduce nicotine content and improve tobacco quality has become one of the most promising methods. Due to increasing interest in nicotine-degrading microorganisms (NDMs), this article reviews recent reports on NDMs, nicotine-degrading enzymes, regulation of nicotine-degrading bacterial consortia and optimization of fermentation conditions, aiming to provide updated references for the in-depth research and application of microorganisms for the degradation of nicotine.

Graphical Abstract

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通过微生物降解降低烟草中尼古丁含量：研究进展和潜在应用

烟草原产于南美洲，现在作为主要经济作物分布在世界各地。尼古丁是烟叶、卷烟烟雾和烟草废弃物的主要有害成分，它不仅严重影响烟叶的风味，而且对人体健康造成极大的危害。20世纪50年代以来，随着反吸烟运动的持续发展，以及消费者对健康和环境保护意识的提高，世界烟草业一直致力于研究、开发和生产对人体健康风险相对较低的低尼古丁卷烟产品。在众多方法中，利用微生物降低烟叶尼古丁含量，提高烟叶质量已成为最有前途的方法之一。随着人们对尼古丁降解微生物（ndm）的兴趣日益增加，本文对ndm、尼古丁降解酶、尼古丁降解菌群调控和发酵条件优化等方面的最新报道进行了综述，旨在为微生物降解尼古丁的深入研究和应用提供最新参考。图形抽象

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来源期刊

Biotechnology for Biofuels 工程技术-生物工程与应用微生物

自引率

0.00%

发文量

审稿时长

2.7 months

期刊介绍： Biotechnology for Biofuels is an open access peer-reviewed journal featuring high-quality studies describing technological and operational advances in the production of biofuels, chemicals and other bioproducts. The journal emphasizes understanding and advancing the application of biotechnology and synergistic operations to improve plants and biological conversion systems for the biological production of these products from biomass, intermediates derived from biomass, or CO2, as well as upstream or downstream operations that are integral to biological conversion of biomass. Biotechnology for Biofuels focuses on the following areas: • Development of terrestrial plant feedstocks • Development of algal feedstocks • Biomass pretreatment, fractionation and extraction for biological conversion • Enzyme engineering, production and analysis • Bacterial genetics, physiology and metabolic engineering • Fungal/yeast genetics, physiology and metabolic engineering • Fermentation, biocatalytic conversion and reaction dynamics • Biological production of chemicals and bioproducts from biomass • Anaerobic digestion, biohydrogen and bioelectricity • Bioprocess integration, techno-economic analysis, modelling and policy • Life cycle assessment and environmental impact analysis