Enhanced ROS generation in AIE-active iridium(iii) photosensitizers by cationization engineering for advanced photodynamic therapy†

IF 6.1 1区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR
Shanshan Huang, Yuancheng Li, Xiaohan Xie, Jialin Tong, Guo-Gang Shan, Chao Qin, Xiyan Xiao, Qianruo Wang, Yuanyuan Li and Hualei Wang
{"title":"Enhanced ROS generation in AIE-active iridium(iii) photosensitizers by cationization engineering for advanced photodynamic therapy†","authors":"Shanshan Huang, Yuancheng Li, Xiaohan Xie, Jialin Tong, Guo-Gang Shan, Chao Qin, Xiyan Xiao, Qianruo Wang, Yuanyuan Li and Hualei Wang","doi":"10.1039/D4QI02477J","DOIUrl":null,"url":null,"abstract":"<p >Phosphorescent iridium(<small>III</small>) complexes have emerged as promising photosensitizers (PSs) for clinical photodynamic therapy (PDT) due to their notable antitumor efficacy. However, their practical application is hindered by weak emission in aggregated states and insufficient reactive oxygen species (ROS) generation. In this study, we present a straightforward cationization strategy aimed at simultaneously enhancing both the emission and ROS production of Ir(<small>III</small>)-based PSs. Two Ir(<small>III</small>) complexes <strong>PPI-C1</strong> and <strong>PPI-C2</strong> which feature an incremental number of hexafluorophosphate counterions were strategically designed through simple ligand engineering of the neutral precursor <strong>PPI-C0</strong>. Both experimental and theoretical analyses reveal that cationization effectively modulates the aggregate behavior and excited-state properties of these complexes, with <strong>PPI-C2</strong> displaying a significantly improved AIE characteristic and effective intersystem crossing ability. As expected, the water-soluble <strong>PPI-C2</strong> nanoparticles showed superior ROS production and good biocompatibility under light irradiation, leading to cell apoptosis and significant inhibition of tumor growth <em>in vivo</em>. This study will offer new insights into the design of effective AIE-active Ir(<small>III</small>)-based photosensitizers for PDT.</p>","PeriodicalId":79,"journal":{"name":"Inorganic Chemistry Frontiers","volume":" 3","pages":" 986-994"},"PeriodicalIF":6.1000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/qi/d4qi02477j","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0

Abstract

Phosphorescent iridium(III) complexes have emerged as promising photosensitizers (PSs) for clinical photodynamic therapy (PDT) due to their notable antitumor efficacy. However, their practical application is hindered by weak emission in aggregated states and insufficient reactive oxygen species (ROS) generation. In this study, we present a straightforward cationization strategy aimed at simultaneously enhancing both the emission and ROS production of Ir(III)-based PSs. Two Ir(III) complexes PPI-C1 and PPI-C2 which feature an incremental number of hexafluorophosphate counterions were strategically designed through simple ligand engineering of the neutral precursor PPI-C0. Both experimental and theoretical analyses reveal that cationization effectively modulates the aggregate behavior and excited-state properties of these complexes, with PPI-C2 displaying a significantly improved AIE characteristic and effective intersystem crossing ability. As expected, the water-soluble PPI-C2 nanoparticles showed superior ROS production and good biocompatibility under light irradiation, leading to cell apoptosis and significant inhibition of tumor growth in vivo. This study will offer new insights into the design of effective AIE-active Ir(III)-based photosensitizers for PDT.

Abstract Image

通过阳离子化工程增强aie活性铱(III)光敏剂中ROS的生成,用于先进的光动力治疗
磷光铱(III)配合物因其显著的抗肿瘤作用而成为临床光动力治疗(PDT)中有前途的光敏剂(ps)。然而,它们的实际应用受到聚集态弱发射和活性氧(ROS)生成不足的阻碍。在本研究中,我们提出了一种直接的阳离子化策略,旨在同时提高Ir(III)基ps的发射和ROS的产生。通过对中性前体PPI-C0进行简单配体工程,设计了具有增量六氟磷酸反离子的两个Ir(III)配合物PPI-C1和PPI-C2。实验和理论分析均表明,阳离子化有效调节了这些配合物的聚集行为和激发态性质,PPI-C2表现出显著改善的AIE特性和有效的系统间交叉能力。正如预期的那样,水溶性PPI-C2纳米颗粒在光照射下表现出优越的ROS生成和良好的生物相容性,导致细胞凋亡,并在体内显著抑制肿瘤生长。该研究将为有效的aie活性Ir(III)基光敏剂的PDT设计提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Inorganic Chemistry Frontiers
Inorganic Chemistry Frontiers CHEMISTRY, INORGANIC & NUCLEAR-
CiteScore
10.40
自引率
7.10%
发文量
587
审稿时长
1.2 months
期刊介绍: The international, high quality journal for interdisciplinary research between inorganic chemistry and related subjects
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信