Synthesis of Biological Studies of 3-Trideuteromethylated Chromones and their Heteroatom Analogues

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-18 DOI:10.1039/d4qo02081b

Kaiyue Yang, Dongke Zhang, Ce Yang, Xueyan Yang, Jiaxin He, Haofeng Shi, Zichuan Liu, Yunfei Du

引用次数: 0

Abstract

The bioactive trideuteromethylated chromones and their heteroatom analogues were synthesized via trideuteromethylation of chromones and their heteroatom analogues by utilizing Fenton's reagent system with d6-DMSO as the “CD3” source. Mechanistically, it was postulated that the hydroxyl radical generated from Fenton's reagent system first reacted with d6-DMSO to give the electrophilic trideuteromethyl radical, which underwent radical substitution with chromones and their heteroatom analogues to give the title products. The obtained trideuteromethylated compounds were subjected to biological studies and the results revealed that this class of trideuteromethylated chromones and their heteroatom analogues exhibit good to excellent in vitro anti-lung carcinoma and anti-hepatoma activities.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.