Incidence, risk factors, and epidemiological trends of tracheal cancer: a global analysis

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2024-12-18 DOI:10.1186/s12943-024-02188-4

Junjie Huang, Mingtao Chen, Lin Zhang, Xu Lin, Don Eliseo Lucero-Prisno, Claire Chenwen Zhong, Wanghong Xu, Zhi-Jie Zheng, Mellissa Withers, Martin C. S. Wong

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引用次数: 0

Abstract

Tracheal cancer is a rare malignancy with limited research but high mortality rates. This study aims to analyse recent data to understand the global burden, trends, and risk factors for tracheal cancer, facilitating improved prevention and treatment strategies. We conducted a study on tracheal cancer using data from the Global Cancer Observatory and the Cancer Incidence in Five Continents databases. We collected information on the incidence of tracheal cancer, risk factors, and the Human Development Index (HDI) at the country level. The univariate linear regression was used to explore the relationship between tracheal cancer and the various risk factors. We utilised joinpoint regression analysis to calculate the Average Annual Percentage Change (AAPC) in tracheal cancer incidence. The global age-standardised rate of incidence of tracheal cancer was 2.9 per 10 million (3,472 cases in total) in 2022, with the highest regional incidence observed in Central and Eastern Europe (ASR = 9.0) and the highest national incidence in Hungary (12.5). Higher incidence was found among the males (3.8) than females (2.0); among the older adults aged 50-74 (11.9) than the younger population aged 15-49 (1.2). A higher tracheal cancer incidence ratio was associated with higher levels of smoking, alcohol drinking, diabetes, lipid disorders, and HDI. Despite the overall decreasing trends for all population groups (highest decrease in Thailand; AAPC: -15.06, 95% CI: -21.76 to -7.78, p = 0.002), there was an increase in some female populations (highest increase in Colombia, AAPC: 19.28, 95% CI: 16.48 to 22.15, p < 0.001) and younger populations (highest increase in Ireland; AAPC: 29.84, 95% CI: 25.74 to 34.06, p < 0.001). This study provides a comprehensive analysis of tracheal cancer, focusing on risk factors and population-level trends. There has been an overall decreasing trend in the incidence of tracheal cancer, particularly among males and older adults, while the decline is less pronounced in females and younger individuals. Further research is needed to explore the underlying drivers of these epidemiological trends.

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气管癌是一种罕见的恶性肿瘤，研究有限，但死亡率很高。本研究旨在分析最新数据，以了解气管癌的全球负担、趋势和风险因素，从而改进预防和治疗策略。我们利用全球癌症观察站和五大洲癌症发病率数据库的数据对气管癌进行了研究。我们收集了有关气管癌发病率、风险因素和国家层面人类发展指数（HDI）的信息。我们采用单变量线性回归法来探讨气管癌与各种风险因素之间的关系。我们利用连接点回归分析来计算气管癌发病率的年均百分比变化（AAPC）。2022 年，全球气管癌的年龄标准化发病率为每 1,000 万人 2.9 例（共 3,472 例），中东欧的地区发病率最高（ASR = 9.0），匈牙利的全国发病率最高（12.5）。男性发病率（3.8）高于女性（2.0）；50-74 岁的老年人发病率（11.9）高于 15-49 岁的年轻人（1.2）。气管癌发病率较高与吸烟、饮酒、糖尿病、血脂紊乱和人类发展指数较高有关。尽管所有人群的气管癌发病率总体呈下降趋势（泰国降幅最大；AAPC：-15.06，95% CI：-21.76 至 -7.78，p = 0.002），但一些女性人群（哥伦比亚增幅最大，AAPC：19.28，95% CI：16.48 至 22.15，p < 0.001）和年轻人群（爱尔兰增幅最大；AAPC：29.84，95% CI：25.74 至 34.06，p < 0.001）的发病率有所上升。本研究对气管癌进行了全面分析，重点关注风险因素和人群趋势。气管癌的发病率总体呈下降趋势，尤其是男性和老年人，而女性和年轻人的下降趋势则不太明显。需要进一步开展研究，探索这些流行病学趋势的根本原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.