An integrative data-driven model simulating C. elegans brain, body and environment interactions

IF 12 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Mengdi Zhao, Ning Wang, Xinrui Jiang, Xiaoyang Ma, Haixin Ma, Gan He, Kai Du, Lei Ma, Tiejun Huang
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Abstract

The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either the brain or the body–environment. Here we present BAAIWorm, an integrative data-driven model of Caenorhabditis elegans, which consists of two submodels: the brain model and the body–environment model. The brain model was built by multicompartment models with realistic morphology, connectome and neural population dynamics based on experimental data. Simultaneously, the body–environment model used a lifelike body and a three-dimensional physical environment. Through the closed-loop interaction between the two submodels, BAAIWorm reproduced the realistic zigzag movement toward attractors observed in C. elegans. Leveraging this model, we investigated the impact of neural system structure on both neural activities and behaviors. Consequently, BAAIWorm can enhance our understanding of how the brain controls the body to interact with its surrounding environment. BAAIWorm is an integrative data-driven model of C. elegans that simulates interactions between the brain, body and environment. The biophysically detailed neuronal model is capable of replicating the zigzag movement observed in this species.

Abstract Image

模拟秀丽隐杆线虫大脑、身体和环境相互作用的综合数据驱动模型。
生物体的行为受到其大脑、身体和环境之间复杂的相互作用的影响。现有的数据驱动模型要么关注大脑,要么关注身体环境。在这里,我们提出了BAAIWorm,一个综合数据驱动的秀丽隐杆线虫模型,它包括两个子模型:大脑模型和身体环境模型。以实验数据为基础,采用具有真实形态学、连接体和神经种群动态的多室模型构建脑模型。同时,身体环境模型使用了逼真的身体和三维的物理环境。通过两个子模型之间的闭环相互作用,BAAIWorm复制了秀丽隐杆线虫中观察到的真实的吸引子之字形运动。利用这个模型,我们研究了神经系统结构对神经活动和行为的影响。因此,BAAIWorm可以增强我们对大脑如何控制身体与周围环境相互作用的理解。
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CiteScore
11.70
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