A misstep in the multistep process of fast inactivation.

IF 3.3 2区医学 Q1 PHYSIOLOGY

Journal of General Physiology Pub Date : 2025-01-06 Epub Date: 2024-12-17 DOI:10.1085/jgp.202413735

Ben Short

引用次数: 0

Abstract

JGP study (Liu and Bezanilla. https://doi.org/10.1085/jgp.202413667) reveals that a sodium channel mutant blocks fast inactivation downstream of inactivation particle binding, diverting the channel into an alternative open state.

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多步骤快速失活过程中的一个失误。

JGP 研究（Liu 和 Bezanilla. https://doi.org/10.1085/jgp.202413667）发现，钠通道突变体阻断了失活粒子结合下游的快速失活，使通道转入另一种开放状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of General Physiology 医学-生理学

CiteScore

6.00

自引率

10.50%

发文量

审稿时长

6-12 weeks

期刊介绍： General physiology is the study of biological mechanisms through analytical investigations, which decipher the molecular and cellular mechanisms underlying biological function at all levels of organization. The mission of Journal of General Physiology (JGP) is to publish mechanistic and quantitative molecular and cellular physiology of the highest quality, to provide a best-in-class author experience, and to nurture future generations of independent researchers. The major emphasis is on physiological problems at the cellular and molecular level.