Association Between Patient-Reported Pain and Remission or Low Disease Activity in Patients with Rheumatoid Arthritis: Data from RA-BE-REAL Prospective Observational Study.

IF 2.9 3区医学 Q2 RHEUMATOLOGY

Rheumatology and Therapy Pub Date : 2024-12-17 DOI:10.1007/s40744-024-00732-8

Peter C Taylor, Walid Fakhouri, Samuel Ogwu, Ewa Haladyj, Inmaculada de la Torre, Bruno Fautrel, Rieke Alten, Peter Nash, Eugen Feist

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引用次数: 0

Abstract

Introduction: We aim to assess the association of patient-reported pain and remission or low disease activity (LDA) at 3 months (M) in patients receiving baricitinib or other treatments in RA-BE-REAL.

Methods: RA-BE-REAL reports on patients with rheumatoid arthritis (RA) who were prescribed, for the first time, baricitinib (cohort A) or a tumour necrosis factor inhibitor (TNFi) (cohort B-TNFi) or any other mode of action (OMA) (cohort B-OMA). Pain was measured using the visual analogue scale (VAS) (0-100 mm) and clinically meaningful pain improvement thresholds of ≥ 30%, ≥ 50% and ≥ 70% from baseline to 3, 6, 12 and 24 M.

Results: At 3 M, the mean change from baseline (CFB) pain VAS of patients in remission/LDA was - 32.6 mm (cohort A), - 27.3 mm (cohort B-TNFi) and - 28.0 mm (cohort B-OMA). Almost half the patients who were in remission/LDA receiving baricitinib achieved ≥ 70% pain relief. At 3 M, the proportion of patients in remission/LDA with pain VAS ≤ 20 mm was 62.1% (cohort A), 55.0% (cohort B-TNFi) and 55.6% (cohort B-OMA), while for those not in remission/LDA, it was 8.5% and 8.7% (cohort A and B-TNFi, respectively) and 5.3% (B-OMA). More patients on baricitinib achieved pain improvement in all analyzed thresholds than patients in cohort B-TNFi and B-OMA at 3 M. At 24 M, - 26.2 mm (cohort A), - 20.8 mm (cohort B-TNFi) and - 16.0 mm (cohort B-OMA) mean CFBs in pain measurement were observed. For baricitinib and the other treatments, residual pain decreased with achievement of remission/LDA and was sustained up to 24 M.

Conclusions: Patients in remission/LDA receiving baricitinib are more likely to achieve pain control than patients receiving TNFi/OMA.

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简介：我们旨在评估在RA-BE-REAL中接受巴利昔替尼或其他治疗的患者3个月（M）时患者报告的疼痛与缓解或低疾病活动度（LDA）之间的关联：RA-BE-REAL报告了首次接受巴利昔尼（A组）或肿瘤坏死因子抑制剂（TNFi）（B组-TNFi）或任何其他作用模式（OMA）（B组-OMA）治疗的类风湿性关节炎（RA）患者的情况。疼痛采用视觉模拟量表（VAS）（0-100 毫米）进行测量，从基线到 3、6、12 和 24 个月的临床意义疼痛改善阈值分别为≥30%、≥50% 和≥70%：3 M时，缓解/LDA患者疼痛VAS从基线（CFB）的平均变化为- 32.6 mm（队列A）、- 27.3 mm（队列B-TNFi）和- 28.0 mm（队列B-OMA）。在接受巴利昔尼治疗的缓解/LDA患者中，近一半患者的疼痛缓解率≥70%。3 M时，疼痛VAS≤20 mm的缓解/LDA患者比例分别为62.1%（队列A）、55.0%（队列B-TNFi）和55.6%（队列B-OMA），而未缓解/LDA患者的比例分别为8.5%和8.7%（队列A和队列B-TNFi）和5.3%（队列B-OMA）。与 B-TNFi 和 B-OMA 组患者相比，更多的巴利昔替尼患者在 3 个月后的所有分析阈值上都获得了疼痛改善。在 24 个月后，观察到疼痛测量的平均 CFB 为-26.2 毫米（A 组）、-20.8 毫米（B-TNFi 组）和-16.0 毫米（B-OMA 组）。巴利昔尼和其他治疗方法的残余疼痛随着缓解/LDA的实现而减少，并持续到24个月：结论：与接受 TNFi/OMA 治疗的患者相比，接受巴利昔尼治疗的缓解/LDA 患者更有可能实现疼痛控制。

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来源期刊

Rheumatology and Therapy RHEUMATOLOGY-

CiteScore

6.00

自引率

5.30%

发文量

审稿时长

6 weeks

期刊介绍： Aims and Scope Rheumatology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of rheumatologic therapies. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. Areas of focus include, but are not limited to, rheumatoid arthritis, gout, gouty arthritis, psoriatic arthritis, osteoarthritis, juvenile idiopathic/rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis, Pompe’s disease, inflammatory joint conditions, musculoskeletal conditions, systemic sclerosis, and fibromyalgia. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial protocols, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Rheumatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research. Ethics and Disclosures The journal is a member of the Committee on Publication Ethics (COPE) and subscribes to its principles on how to deal with acts of misconduct thereby committing to investigate allegations of misconduct in order to ensure the integrity of research. Content in this journal is peer-reviewed (Single-blind). For more information on our publishing ethics policies, please see here: https://www.springer.com/gp/editorial-policies Rapid Publication The journal’s rapid publication timelines aim for a peer review decision within 2 weeks of submission. If an article is accepted it will be published online 3-4 weeks from acceptance. These rapid timelines are achieved through the combination of a dedicated in-house editorial team, who closely manage article workflow, and an extensive Editorial and Advisory Board who assist with rapid peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid and efficient communication of the latest research and reviews, allowing the advancement of rheumatologic therapies. 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