Aerobic Reconstruction of Amines to Amides: A C–N/C–C Bond Cleavage Approach

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-12-16 DOI:10.1021/acs.orglett.4c04366

Qinyue Tao, Yanling Zheng, Qiang Li, Yang Long, Jing Wang, Zewei Jin, Xiangge Zhou

引用次数: 0

Abstract

Herein, an aerobic reconstruction of amines to amides via C(sp³)–N bond and C(sp²)–C(sp³) bond cleavage is described. This method features a metal-free reaction, insensitivity to oxygen or moisture, and ambient air as the terminal oxidant. Preliminary mechanistic studies suggest that the reaction pathway of amine oxidation, followed by imine exchange and Beckmann rearrangement, is involved.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.