Recent advances in the application of calcium(ii) triflimide in organic synthesis

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-17 DOI:10.1039/D4QO02164A

Haoran Li, Minyao Kuang, Yuwei Liu, Wei Yi and Shengdong Wang

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Abstract

Calcium(II) triflimide, which is known for its environmentally friendly characteristics, has emerged as a sustainable substitute for transition metal catalysts, rare-earth metals, and strong Brønsted acids in promoting organic synthesis. This advancement has attracted substantial attention from the scientific community. Recently, sophisticated methodologies incorporating calcium(II) triflimide have been devised, such as cyclizations, dehydrative functionalizations, hydroarylation reactions, hydrofunctionalizations, reductions, rearrangements, and novel selenylations. These have been applied to a wide variety of substrates, including alcohols, alkenes, alkynes, carbonyl compounds, imines, N,O-acetals, and selenides, for the formation of C–C or C–X bonds. The objective of this review is to offer a thorough and meticulous overview of the recent progress in the utilization of calcium(II) triflimide as a catalyst in organic synthesis, summarizing the significant achievements in reaction methodologies and the probable reaction mechanisms.

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三亚甲基钙（II）在有机合成中的最新进展

在促进有机合成方面，无害环境的三亚甲基钙（II）已成为过渡金属催化剂、稀土金属和强勃氏酸的可持续替代品，因而备受关注。最近，人们开发出了涉及三亚甲基钙（II）的优雅方法，如环化、脱水官能化、加氢反应、加氢官能化、还原、重排和新型硒化反应，这些方法已被应用于多种底物，包括醇、烯烃、炔烃、羰基化合物、亚胺、N,O-乙醛和硒化物，以形成 C-C 或 C-X 键。这篇综述全面而详细地概述了三亚甲基钙（II）作为有机合成催化剂的最新应用进展，总结了反应方法学方面的重要成果和合理的反应机理。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.