Zihe Cheng, Sébastien Perrier, Qiao Song, Stephen Hall
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引用次数: 0
Abstract
Self-assembling cyclic peptide nanotubes are fascinating supramolecular systems with promising potential for various applications, such as drug delivery, transmembrane ionic channels, and artificial light-harvesting systems. In this study, we present novel pH-responsive nanotubes based on asymmetric cyclic peptide-polymer conjugates. The pH response is introduced by a tertiary amine-based polymer, poly(dimethylamino ethyl methacrylate) (pDMAEMA) or poly(diethylamino ethyl methacrylate) (pDEAEMA) which is quaternised at low pH. The self-assembling behaviour of their corresponding conjugates is investigated using different scattering and spectroscopy techniques. Compared to conjugates with hydrophilic polymeric corona, the introduction of hydrophobic polymer chains on the periphery of the cyclic peptides can prevent water molecules from penetrating through to the peptide rings, allowing the construction of hydrogen bonding interactions between cyclic peptides to form longer nanotubes. The switching between assembly and non-assembly is triggered by the change in the surrounding environmental pH, which process is controlled by the coordination between hydrophobic interactions and electrostatic repulsions. Due to the different hydrophobicity of these two polymers, the self-assembly of their corresponding conjugates varies extensively. We first demonstrate this evolution in detail and describe the relationship between the self-assembly and the inherent properties of grafted polymers, such as polymer compositions, the protonation degree of the responsive polymers and the polymer molecular weight in solutions.
期刊介绍:
Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.