Mesenchymal stem cell-derived extracellular vesicles: A promising therapeutic strategy in diabetic osteoporosis.

IF 4.2 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Ya-Jing Yang, Xi-Er Chen, Xu-Chang Zhou, Feng-Xia Liang
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Abstract

Diabetic osteoporosis (DOP) is a serious complication of diabetes mellitus. It is urgent to explore efficient clinical treatment strategies for DOP. It has been found that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), as an emerging cell-free therapy, show great potential in DOP treatment. MSC-EVs can effectively promote bone formation, inhibit bone resorption, and modulate the inflammatory microenvironment by delivering cargoes of microRNAs, long non-coding RNAs, and proteins to target cells, thereby ameliorating bone loss in DOP. However, there are limited reports on the treatment of DOP with MSC-EVs. To evoke more attention to this potential strategy, this article summarised the extant literature on MSC-EVs for DOP to provide new directions for further research and to promote the application of MSC-EVs in the clinical management of DOP.

间充质干细胞衍生的细胞外囊泡:糖尿病骨质疏松症的有望治疗策略
糖尿病骨质疏松症(DOP)是糖尿病的一种严重并发症。探索有效的糖尿病骨质疏松症临床治疗策略迫在眉睫。研究发现,间充质干细胞衍生的细胞外囊泡(MSC-EVs)作为一种新兴的无细胞疗法,在糖尿病骨质疏松症的治疗中显示出巨大的潜力。间充质干细胞胞外囊泡可有效促进骨形成、抑制骨吸收,并通过向靶细胞递送微RNA、长非编码RNA和蛋白质等载体来调节炎症微环境,从而改善DOP患者的骨质流失。然而,有关间充质干细胞-EVs 治疗 DOP 的报道并不多。为了唤起人们对这一潜在策略的关注,本文总结了有关间充质干细胞-EVs治疗DOP的现有文献,为进一步研究提供新的方向,并促进间充质干细胞-EVs在DOP临床治疗中的应用。
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来源期刊
World Journal of Diabetes
World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
2.40%
发文量
909
期刊介绍: The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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