The Association of Lipid Abnormalities with Complications in Severe Scrub Typhus.

Q3 Medicine
Ravi Sarswat, Balraj Singh, Akash Singh, Sanjay Mahajan
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引用次数: 0

Abstract

Aim: To study abnormalities of lipids in patients suffering from severe scrub typhus and their relationship with complications.

Methods: This cohort study was conducted in patients of severe scrub typhus [immunoglobulin (IgM) positive by enzyme-linked immunosorbent assay (ELISA)] admitted to our institute from 1st August 2020 through 31st July 2021. The lipid profile was estimated initially at the time of hospitalization. Serum total cholesterol, serum triglyceride levels (TGs), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) were estimated. The association (risk ratios) of lipids abnormalities was determined with mortality, multiple organ dysfunction syndrome (MODS), septic shock, and septic shock with MODS.

Results: We studied 100 patients (mean age of 48.4 ± 16.3 years) of whom 73 (73%) were females. On presentation, fever (91%), myalgias (38%), abdominal pain (16%), shortness of breath (15%), and cough (12%) were main symptoms. On examination, tachypnoea (68%), tachycardia (65%), conjunctival suffusion (37%), icterus (29%), eschar (14%), abdominal tenderness (10%), splenomegaly (4%), and hepatomegaly (3%) were noted. In lipid abnormalities, 93 (93%) patients had low HDL-C (males <40 mg/dL, females <50 mg/dL), serum triglycerides (200 mg/dL) were elevated in 71 (71%) patients, serum total cholesterol (>240 mg/dL) was increased in 4 (4%) patients, and 4 patients had raised serum LDL-C levels (160-189 mg/dL). Sixty-two (62%) patients developed MODS, 16 (16%) had septic shock, 15 (15%) developed septic shock with MODS, and 4 (4%) patients died. High serum TGs (>200 mg/dL) were associated with MODS (RR = 1.6, 95% CI = 1.2-2.0, p = 0.008) and septic shock with MODS (RR = 4.2, 95% CI = 1-17.4, p = 0.022) and the serum LDL-C levels <50 mg/dL were associated with MODS (RR = 1.6, 95% CI = 1.2-2.0, p = 0.007).

Conclusion: There was a significant association of increased severity of scrub typhus with high TGs (>200 mg/dL) levels and low levels of LDL-C (<50 mg/dL) in admitted patients of severe scrub typhus.

脂质异常与严重恙虫病并发症的关系。
目的:探讨重度恙虫病患者血脂异常及其与并发症的关系。方法:本队列研究纳入了2020年8月1日至2021年7月31日在我所收治的重症恙虫病[酶联免疫吸附试验(ELISA)免疫球蛋白(IgM)阳性]患者。脂质谱在住院时初步估计。测定血清总胆固醇、血清甘油三酯水平(tg)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)。血脂异常与死亡率、多器官功能障碍综合征(MODS)、感染性休克以及感染性休克合并MODS的相关性(风险比)被确定。结果:100例患者(平均年龄48.4±16.3岁),其中73例(73%)为女性。在就诊时,主要症状为发热(91%)、肌痛(38%)、腹痛(16%)、呼吸短促(15%)和咳嗽(12%)。检查时,发现呼吸急促(68%)、心动过速(65%)、结膜充盈(37%)、黄疸(29%)、焦痂(14%)、腹部压痛(10%)、脾肿大(4%)和肝肿大(3%)。在脂质异常中,93例(93%)患者HDL-C水平低(男性240 mg/dL), 4例(4%)患者血清LDL-C水平升高(160-189 mg/dL)。62例(62%)患者发生MODS, 16例(16%)患者发生感染性休克,15例(15%)患者合并MODS并发感染性休克,4例(4%)患者死亡。高血清TGs (>200 mg/dL)与MODS (RR = 1.6, 95% CI = 1.2 ~ 2.0, p = 0.008)和脓毒性休克合并MODS (RR = 4.2, 95% CI = 1 ~ 17.4, p = 0.022)及血清LDL-C水平p = 0.007相关。结论:高TGs (bb0 ~ 200mg /dL)水平和低LDL-C (LDL-C)水平与恙虫病严重程度升高有显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
509
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