Expeditious Synthesis, Characterization, and Antimicrobial Assessment of Thiazole Derivatives

Abstract

Objective: This study aims to explore the antimicrobial potential of thiazole derivatives and their significance as promising pharmaceutical agents, given their diverse therapeutic applications, including anticancer, antibacterial, antiviral, antihypertensive, and antifungal activities. Methods: An efficient synthetic route was established to synthesize a range of ethyl(E)-2-(4-hydroxy-3-((phenylimino)methyl)phenyl)-5-methylthiazole-4-carboxylate derivatives (VIIa–VIIj). Structural elucidation of these newly synthesized compounds utilized advanced techniques, such as ¹H, ¹³C NMR, FT-IR spectroscopy, mass spectrometry, and elemental analysis, ensuring accurate identification and characterization. Furhter, all the synthesized compounds were evaluated for their antimicrobial potential against various bacterial and fungal strains. Results and Discussion: In the results, it is found that compounds (VIIa), (VIId), (VIIe), and (VIIg) shows good antibacterial activity while compounds (VIIb) and (VIIc) shows good antifungal activity, suggesting their possible utility in clinical contexts. Conclusions: This research provides valuable insights into the therapeutic potential of thiazole derivatives, paving the way for future investigations into their clinical implications for addressing microbial challenges.