Radiomics based on dual-layer spectral detector CT for predicting EGFR mutation status in non-small cell lung cancer.

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Dan Jin, Xiaoqiong Ni, Yanhuan Tan, Hongkun Yin, Guohua Fan
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引用次数: 0

Abstract

Objective: To explore the value of dual-layer spectral computed tomography (DLCT)-based radiomics for predicting epidermal growth factor receptor (EGFR) mutation status in patients with non-small cell lung cancer (NSCLC).

Methods: DLCT images and clinical information from 115 patients with NSCLC were collected retrospectively and randomly assigned to a training group (n = 81) and a validation group (n = 34). A radiomics model was constructed based on the DLCT radiomic features by least absolute shrinkage and selection operator (LASSO) dimensionality reduction. A clinical model based on clinical and CT features was established. A nomogram was built combining the radiomic scores (Radscores) and clinical factors. Receiver operating characteristic (ROC) analysis and decision curve analysis (DCA) were used for the efficacy and clinical value of the models assessment.

Results: A total of six radiomic features and two clinical features were screened for modeling. The AUCs of the radiomic model, clinical model, and nomogram were 0.909, 0.797, and 0.922, respectively, in the training group and 0.874, 0.691, and 0.881, respectively, in the validation group. The AUCs of the nomogram and the radiomics model were significantly higher than that of the clinical model, but no significant difference was found between them. DCA revealed that nomogram had the greatest clinical benefit at most threshold intervals.

Conclusion: Nomogram integrating clinical factors and pretreatment DLCT radiomic features can help evaluate the EGFR mutation status of patients with NSCLC in a noninvasive way.

目的探讨基于双层光谱计算机断层扫描(DLCT)的放射组学在预测非小细胞肺癌(NSCLC)患者表皮生长因子受体(EGFR)突变状态方面的价值:回顾性收集115名NSCLC患者的DLCT图像和临床信息,并随机分配到训练组(81人)和验证组(34人)。通过最小绝对收缩和选择算子(LASSO)降维,基于DLCT放射组学特征构建放射组学模型。根据临床和 CT 特征建立了临床模型。结合放射学评分(Radscores)和临床因素建立了一个提名图。接收者操作特征(ROC)分析和决策曲线分析(DCA)用于评估模型的有效性和临床价值:结果:共筛选出六个放射学特征和两个临床特征用于建模。训练组的放射学模型、临床模型和提名图的AUC分别为0.909、0.797和0.922,验证组的AUC分别为0.874、0.691和0.881。提名图和放射组学模型的 AUC 明显高于临床模型,但两者之间没有发现显著差异。DCA显示,在大多数阈值区间,提名图的临床获益最大:综合临床因素和治疗前DLCT放射学特征的提名图有助于以非侵入性的方式评估NSCLC患者的表皮生长因子受体突变状态。
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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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