Pharmacological treatments for co-occurring PTSD and substance use disorders: A systematic review

0 PSYCHOLOGY, CLINICAL

Journal of substance use and addiction treatment Pub Date : 2025-02-01 DOI:10.1016/j.josat.2024.209601

Megan Swannell , Richard C.J. Bradlow , Daniel Pham , Jessica Gabriel , Yasmin Manahan , Shalini Arunogiri

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引用次数: 0

Abstract

Introduction

Post-traumatic stress disorder and substance use disorders commonly co-occur and are associated with worse health outcomes. Currently, only psychosocial therapies are specifically recommended for use in the co-occurring population, but these come with numerous barriers to access and engagement. This study aims to identify potential pharmacological treatments to enhance treatment options and outcomes for this population.

Methods

This systematic review identified studies on pharmacological treatment of co-occurring PTSD and SUD in humans, using validated outcome measurements, with study design of RCT, observational study, case control study or cohort study.

Results

29 studies were identified for inclusion, looking at a range of 16 pharmacotherapies. A majority concentrated on alcohol use disorders and males, with many focused on the veteran population.

Conclusions

This is an area for further research, inclusive of more SUDs, genders and civilians. Future studies utilizing consistent dosing, populations and measurement outcomes will allow for future meta-analysis.

查看原文本刊更多论文

共同发生的PTSD和物质使用障碍的药物治疗：系统回顾。

简介：创伤后应激障碍和物质使用障碍通常同时发生，并与较差的健康结果相关。目前，只有社会心理疗法被特别推荐用于同时发生的人群，但这些疗法在获得和参与方面存在许多障碍。本研究旨在确定潜在的药物治疗方法，以提高这一人群的治疗选择和结果。方法：本系统综述采用随机对照试验、观察性研究、病例对照研究或队列研究，采用有效的结果测量方法，对人类并发PTSD和SUD的药物治疗进行了研究。结果：纳入了29项研究，包括16种药物治疗方法。大多数研究集中在酒精使用障碍和男性身上，其中许多研究集中在退伍军人身上。结论：这是一个需要进一步研究的领域，包括更多的sud、性别和平民。未来的研究采用一致的剂量、人群和测量结果，将允许未来的荟萃分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of substance use and addiction treatment Biological Psychiatry, Neuroscience (General), Psychiatry and Mental Health, Psychology (General)

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