Longitudinal DTI analysis of microstructural changes in lumbar nerve roots following Interspinous process device placement

IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
L. Monti , M. Bellini MD , M. Alberti , E. Piane , T. Casseri , G. Sadotti , S. Marcia , J.A. Hirsc , F. Ginanneschi , A. Rossi
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引用次数: 0

Abstract

Diffusion tensor imaging (DTI) and its parameters such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD) are increasingly being used to assess peripheral nerve integrity alongside nerve conduction studies. This pilot study aims to compare DTI values of lumbar spinal nerve roots before (T0) and after (T1) treatment with an interspinous process device (IPD). Seven patients (5 females, 2 males; mean age: 68) suffering from neurogenic claudication and lumbar spinal canal and foraminal stenosis were evaluated. Visual Analog Scale (VAS) for perceived pain, Oswestry Disability Index (ODI), and DTI parameters were assessed between T0 and T1. No significant difference in FA was found in treated roots, while MD (p = 0.0015), RD (p = 0.0032), and AD (p = 0.0221) were significantly altered. At untreated levels, all DTI parameters showed highly significant differences (p < 0.0001) between T0 and T1. In treated roots, FA values significantly increased in the intraforaminal segment(p = 0.0229), while MD(p = 0.0124), AD(p = 0.0128), and RD (p = 0.0143) values decreased in the pre-foraminal segment. In untreated roots, FA significantly increased in pre(p = 0.0039)and intraforaminal(p = 0.0003) segments, and MD, AD, and RD decreased in all segments (p < 0.0001). VAS (p < 0.0001) also decreased between T0 and T1. This pilot study aims to clarify the biomechanical impact of interspinous spacers through microstructural analysis of both treated and adjacent untreated nerve roots. To our knowledge, no studies have examined the short- to medium-term changes in DTI values of lumbar nerve roots before and after IPD placement, or compared changes between treated and untreated roots.
腰椎神经根棘突间装置置入后显微结构变化的纵向DTI分析。
扩散张量成像(DTI)及其参数如分数各向异性(FA)、平均扩散率(MD)、轴向扩散率(AD)、径向扩散率(RD)与神经传导研究一起越来越多地用于评估周围神经完整性。本初步研究旨在比较棘间突装置(IPD)治疗前(T0)和后(T1)腰脊神经根的DTI值。7例患者(女5例,男2例;平均年龄:68岁)患有神经源性跛行和腰椎管及椎间孔狭窄。在T0和T1之间评估视觉模拟量表(VAS)感知疼痛、Oswestry残疾指数(ODI)和DTI参数。不同处理的根系FA无显著差异,而MD (p = 0.0015)、RD (p = 0.0032)和AD (p = 0.0221)有显著变化。在未处理水平,所有DTI参数显示高度显著差异(p
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来源期刊
Magnetic resonance imaging
Magnetic resonance imaging 医学-核医学
CiteScore
4.70
自引率
4.00%
发文量
194
审稿时长
83 days
期刊介绍: Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
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