Function of Brain-Derived Neurotrophic Factor in the Vestibular-Cochlear System

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemical Research Pub Date : 2024-12-14 DOI:10.1007/s11064-024-04314-6

Bin Zhang, Su-Lan Chen, Xin Teng, Qi Han, Tong Wu, Zhen Yang, Yin Liu, Ke Xiang, Li Sun

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Abstract

Brain-derived neurotrophic factor (BDNF) is essential for the development and functioning of the vestibular system. BDNF promotes the growth, differentiation, and synaptic plasticity of vestibular neurons, ensuring their normal operation and maintenance. According to research, BDNF is pivotal during vestibular compensation, aiding in the recovery of neuron function by remodeling the spontaneous resting potentials of damaged vestibular neurons. Additionally, BDNF exhibits dose-dependent and age-dependent characteristics during vestibular system development, with its deficiencies leading to the degeneration of vestibular neurons. BDNF dynamically interacts with other neurotrophic factors, such as fibroblast growth factor-2 (FGF-2) and glial cell line-derived neurotrophic factor (GDNF), synergistically enhancing neuron survival and functionality. This review outline the function of BDNF in the vestibulocochlear system and explores its potential therapeutic applications, offering fresh perspectives and guidance for future research and treatment of vestibulocochlear system disorders.

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脑源性神经营养因子在前庭-耳蜗系统中的功能

脑源性神经营养因子（BDNF）对前庭系统的发育和功能至关重要。脑源性神经营养因子能促进前庭神经元的生长、分化和突触可塑性，确保其正常运行和维持。研究表明，BDNF 在前庭代偿过程中起着关键作用，它通过重塑受损前庭神经元的自发静息电位来帮助神经元功能的恢复。此外，BDNF 在前庭系统发育过程中表现出剂量依赖性和年龄依赖性特征，其缺乏会导致前庭神经元退化。BDNF与成纤维细胞生长因子-2（FGF-2）和胶质细胞系源性神经营养因子（GDNF）等其他神经营养因子动态相互作用，协同提高神经元的存活率和功能。这篇综述概述了 BDNF 在前庭耳蜗系统中的功能，并探讨了其潜在的治疗应用，为前庭耳蜗系统疾病的未来研究和治疗提供了新的视角和指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.