Photoredox trifluoromethylation of isocyanides to access 2-trifluoromethylated quinolines and indoles

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-12-13 DOI:10.1039/d4qo02105c

Jin Wang, Yaohui Liu, Jinhai Xu, Peiyuan Li, Xiaoxi Xu, Shuo Zhang, Jie Yang, Xianxiu Xu

引用次数: 0

Abstract

We herein report a divergent synthesis of 2-CF₃ substituted quinolines and indoles via photoredox radical trifluoromethylation of ortho-vinylphenylisocyanides. This mild and green protocol offers a broad substrate scope and good functional group tolerance. Mechanistic investigations revealed that the trifluoromethyl radical is generated through an EDA complex between Togni’s reagent and a base under light irradiation.

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异氰酸酯的光氧化三氟甲基化反应生成 2-三氟甲基化的喹啉和吲哚

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.