Rapid detection and classification of pharmaceutical molecules using Ag/ZIF-8/TNTs composite substrate

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2024-12-07 DOI:10.1016/j.saa.2024.125566

Jinmei Chen, Yudong Lu, Chunling Xie, Xiufeng Xiao

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Abstract

Discarded drugs in the ecosystem pose a significant threat to human health and are a global health problem. Therefore, it is essential to establish effective detection and degradation strategies. Metal-organic framework ZIF-8 and Ag NPs were separately grown on titanium dioxide nanotube arrays (TNTs), resulting in the successful synthesis of cost-effective Ag/ZIF-8/TNTs composite substrates. These substrates were able to detect methylene blue (MB) at a low concentration of 1 × 10⁻¹³ M, with a surface-enhanced Raman scattering (SERS) analysis enhancement factor (AEF) of 1.4 × 10⁷, which was higher than other similar substrates. Importantly, the device exhibited high sensitivity and accuracy for rapid detection and classification. Furthermore, this device successfully detected and classified Ibuprofen, Vancomycin, and Doxorubicin with 100 % accuracy using their SERS signatures. Additionally, the Ag/ZIF-8/TNTs substrates showed excellent photocatalytic degradation capability and could be reused without significant loss in activity after five cycles of use. The dual-functional Ag/ZIF-8/TNTs substrates were cost-effective and efficient for the detection and treatment of pollutants in wastewater.

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Ag/ZIF-8/ tnt复合底物对药物分子的快速检测与分类

生态系统中的废弃药物对人类健康构成重大威胁，是一个全球性的健康问题。因此，建立有效的检测和降解策略至关重要。将金属有机骨架ZIF-8和Ag NPs分别生长在二氧化钛纳米管阵列（TNTs）上，成功合成了具有成本效益的Ag/ZIF-8/TNTs复合衬底。该底物在低浓度（1 × 10-13 M）下能够检测亚甲基蓝（MB），其表面增强拉曼散射（SERS）分析增强因子（AEF）为1.4 × 107，高于其他同类底物。重要的是，该装置在快速检测和分类方面具有很高的灵敏度和准确性。此外，该装置利用布洛芬、万古霉素和阿霉素的SERS特征，以100%的准确率成功检测和分类布洛芬、万古霉素和阿霉素。此外，Ag/ZIF-8/ tnt底物表现出优异的光催化降解能力，并且在使用五次循环后可以重复使用而活性没有明显损失。双功能的Ag/ZIF-8/ tnt基板在废水中污染物的检测和处理方面具有成本效益和效率。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.