Raising awareness may increase the likelihood of hematopoietic stem cell donation: a nationwide survey using artificial intelligence.

IF 1.7 4区医学 Q3 HEMATOLOGY

International Journal of Hematology Pub Date : 2024-12-12 DOI:10.1007/s12185-024-03894-x

Luana Conte, Giorgio De Nunzio, Roberto Lupo, Donato Cascio, Marco Cioce, Elsa Vitale, Chiara Ianne, Ivan Rubbi, Massimo Martino, Letizia Lombardini, Aurora Vassanelli, Simonetta Pupella, Simona Pollichieni, Nicoletta Sacchi, Fabio Ciceri, Stefano Botti

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引用次数: 0

Abstract

Background: In Italy, the demand for allogeneic transplantation exceeds the number of compatible donors in the Italian Bone Marrow Donor Registry (IBMDR). This study aimed to explore the knowledge, beliefs, opinions, values, and feelings of the Italian population regarding stem cell donation.

Methods: An online survey was shared via social media. Respondents were retrospectively identified as registered on the IBMDR (donor group) or never registered (non-donor group). Statistical analyses confirmed the relationship between knowledge level and willingness to donate. Six machine learning classifiers were trained using questionnaire responses to predict the probability of IBMDR registration.

Results: A total of 1518 respondents participated. Characteristics identified in the non-donor group were a lower level of knowledge regarding donation needs (51.7% vs 24.4%, p < 0.001) and negative feelings such as fear (Z = - 2.2642, p = 0.02), confusion (Z = 4.4821, p < 0.001), and uncertainty (Z = 3.3425, p < 0.001). Higher knowledge predicted a greater likelihood of IBMDR enrollment. Machine learning analysis showed an AUC ranging from 0.65 to 0.81, depending on the classifier.

Conclusions: The results underscore the need to improve strategies to raise awareness and knowledge of stem cell donation among the Italian population.

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一项使用人工智能的全国性调查显示，提高意识可能会增加造血干细胞捐赠的可能性。

背景：在意大利，同种异体移植的需求超过了意大利骨髓供体登记（IBMDR）中匹配供体的数量。本研究旨在探讨意大利人关于干细胞捐赠的知识、信仰、观点、价值观和感受。方法：通过社交媒体进行在线调查。回答者被回顾性地确定为在IBMDR上登记（捐助者组）或从未登记（非捐助者组）。统计分析证实了知识水平与捐赠意愿之间的关系。使用问卷回答训练六个机器学习分类器来预测IBMDR注册的概率。结果：共1518人参与调查。在非供体组中发现的特征是关于捐赠需求的知识水平较低（51.7%对24.4%）。结论：结果强调需要改进策略，以提高意大利人群对干细胞捐赠的认识和知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hematology 医学-血液学

CiteScore

3.90

自引率

4.80%

发文量

223

审稿时长

6 months

期刊介绍： The International Journal of Hematology, the official journal of the Japanese Society of Hematology, has a long history of publishing leading research in hematology. The journal comprises articles that contribute to progress in research not only in basic hematology but also in clinical hematology, aiming to cover all aspects of this field, namely, erythrocytes, leukocytes and hematopoiesis, hemostasis, thrombosis and vascular biology, hematological malignancies, transplantation, and cell therapy. The expanded [Progress in Hematology] section integrates such relevant fields as the cell biology of stem cells and cancer cells, and clinical research in inflammation, cancer, and thrombosis. Reports on results of clinical trials are also included, thus contributing to the aim of fostering communication among researchers in the growing field of modern hematology. The journal provides the best of up-to-date information on modern hematology, presenting readers with high-impact, original work focusing on pivotal issues.