Non-invasive evaluation of Achilles tendon and its enthesis using ultrashort echo time adiabatic T1ρ (UTE-Adiab-T1ρ) magnetic resonance imaging (MRI) in psoriatic arthritis

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-02-01 DOI:10.1016/j.ejrad.2024.111841

Dina Moazamian , Hamidreza Shaterian Mohammadi , Jiyo Athertya , Mahyar Daskareh , Yajun Ma , Monica Guma , Dana C. Covey , Tony Yaksh , Abha Singh , Arthur Kavanaugh , Christine B. Chung , Jiang Du , Eric Y. Chang , Saeed Jerban

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引用次数: 0

Abstract

Purpose

This cross-sectional study investigates the utility of the quantitative ultrashort echo time (UTE) adiabatic T_1ρ (UTE-Adiab-T_1ρ) magnetic resonance imaging (MRI) in detecting potential differences in Achilles tendons and entheses of patients with psoriatic arthritis disease (PsA) compared with asymptomatic volunteers.

Material and Method

The Achilles tendons of forty-four PsA patients (59 ± 15 years old, 38 % female) and thirty-seven asymptomatic volunteers (32 ± 10 years old, 51 % female) were scanned on a 3 T clinical scanner in the sagittal plane using a 3-inch surface coil. The 3D UTE-Adiab-T_1ρ sequences with fat saturation (FS) were used to measure UTE-Adiab-T_1ρ. Tenderness of the tendons, the SF-12 health survey, and visual analog scale (VAS) were recorded for the patients. The Kruskal Wallis test was used to examine the differences in UTE-Adiab-T1_ρ values between asymptomatic volunteers and patients, as well as subgroups of patients with pain in the Achilles tendon region and those treated with Biologics. Spearman’s correlation coefficients were calculated between UTE-Adiab-T_1ρ and patient evaluations. P values < 0.05 were considered significant.

Results

UTE-Adiab-T_1ρ was significantly higher for the PsA group compared with the asymptomatic group in the enthesis (11.4 ± 2.6 ms vs. 10.4 ± 2.4 ms) and tensile tendon regions (9.8 ± 2.8 ms vs. 7.7 ± 1.7 ms). PsA patients with active Achilles pain showed significantly lower T1ρ in the entheses compared with other patients (10.7 ± 2.6 ms vs. 11.7 ± 2.5 ms). PsA patients treated with Biologics showed significantly lower T_1ρ values in the tendon compared with other patients (9.5 ± 2.5 ms vs. 10.3 ± 3.3 ms). The VAS score of patients showed a significant negative but weak correlation (R = -0.2) with UTE-Adiab-T1ρ of the enthesis. Correlations with SF-12 scores were not significant.

Conclusion

This study highlighted the UTE-Adiab-T_1ρ sequence capability in evaluating tendons and entheses and their potential involvement in PsA disease or response to therapies.

查看原文本刊更多论文

利用超短回波时间绝热 T1ρ (UTE-Adiab-T1ρ) 磁共振成像 (MRI) 对银屑病关节炎患者的跟腱及其内膜进行无创评估。

目的：本横断面研究探讨定量超短回波时间（UTE）绝热T1ρ (UTE- adiab -T1ρ)磁共振成像（MRI）在检测银屑病关节炎（PsA）患者与无症状志愿者跟腱和关节的潜在差异中的应用。材料和方法：采用3英寸表面线圈，在3t临床扫描仪矢状面扫描44例PsA患者（59±15岁，女性38%）和37例无症状志愿者（32±10岁，女性51%）的跟腱。采用脂肪饱和度（FS）的三维UTE-Adiab-T1ρ序列测定UTE-Adiab-T1ρ。记录患者的肌腱压痛、SF-12健康调查和视觉模拟评分（VAS）。Kruskal Wallis检验用于检查无症状志愿者和患者之间的UTE-Adiab-T1ρ值的差异，以及跟腱区域疼痛患者和接受生物制剂治疗的患者亚组之间的差异。计算UTE-Adiab-T1ρ与患者评价之间的Spearman相关系数。结果：PsA组在端骨区（11.4±2.6 ms比10.4±2.4 ms）和张力肌腱区（9.8±2.8 ms比7.7±1.7 ms）的UTE-Adiab-T1ρ显著高于无症状组。伴有活动性跟腱疼痛的PsA患者髋部T1ρ明显低于其他患者（10.7±2.6 ms比11.7±2.5 ms）。与其他患者相比，接受Biologics治疗的PsA患者的肌腱T1ρ值显著降低（9.5±2.5 ms vs 10.3±3.3 ms）。患者VAS评分与端部UTE-Adiab-T1ρ呈显著负但弱相关（R = -0.2）。与SF-12评分的相关性不显著。结论：本研究强调了UTE-Adiab-T1ρ序列在评估肌腱和囊肿及其与PsA疾病或治疗反应的潜在参与方面的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.