Diagnostic Value of Joint Detection of Serum TK1, TSGF, CA199, and CA724 for Gastric Cancer and Its Relationship With Clinicopathologic Features and Prognosis.

IF 1 4区医学 Q3 SURGERY

American Surgeon Pub Date : 2024-12-12 DOI:10.1177/00031348241307397

Aiwen Sun, Hui Chen, Xiaojuan Shi, Zhanmin Shang, Jishun Zhang

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引用次数: 0

Abstract

Objective: To assess the diagnostic value of joint detection of serum TK1, TSGF, CA199, and CA724 for gastric cancer and its relationship with clinicopathologic features and prognosis.

Methods: The 105 gastric cancer patients were enrolled. The diagnostic value of serum TK1, TSGF, CA199, and CA724 for gastric cancer and the relationship between these indicators and the clinicopathologic characteristics of gastric cancer patients were evaluated. During the follow-up period, recurrence, metastasis, and death were considered as poor prognosis. The relationships between serum TK1, TSGF, CA199, and CA724 levels and poor prognosis and factors affecting the poor prognosis of gastric cancer patients were analyzed.

Results: TK1, TSGF, CA199, and CA724 levels in the gastric cancer group were higher; serum TK1, TSGF, CA199, and CA724 levels were higher in gastric cancer patients with tumor diameters ≥3 cm, TNM stages III and IV, low/moderate degree of differentiation, infiltration depths of the muscular or plasma layer, and lymphatic metastases; AUC of combined TK1, TSGF, CA199, and CA724 (0.894) was higher than that of the four indicators alone; the percentage of gastric cancer patients with poor prognosis in patients with low serum TK1, TSGF, CA199, and CA724 levels was lower; serum TK1, TSGF, CA199, and CA724 levels were factors influencing poor prognosis of gastric cancer patients (all P < 0.05).

Conclusion: Elevated serum levels of TK1, TSGF, CA199, and CA724 are associated with clinicopathologic features and poor prognosis of gastric cancer and may be used as serum biomarkers for prognostic evaluation of gastric cancer patients.

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血清TK1、TSGF、CA199、CA724联合检测对胃癌的诊断价值及其与临床病理特征及预后的关系

目的：探讨血清TK1、TSGF、CA199、CA724联合检测对胃癌的诊断价值及其与临床病理特征及预后的关系。方法：选取105例胃癌患者。评价血清TK1、TSGF、CA199、CA724对胃癌的诊断价值，以及这些指标与胃癌患者临床病理特征的关系。在随访期间，复发、转移和死亡被认为预后不良。分析胃癌患者血清TK1、TSGF、CA199、CA724水平与预后不良的关系及影响预后不良的因素。结果：胃癌组TK1、TSGF、CA199、CA724水平升高；血清TK1、TSGF、CA199、CA724水平在肿瘤直径≥3cm、TNM分期为III期和IV期、低/中度分化、肌层或浆层浸润深度及淋巴转移的胃癌患者中较高；TK1、TSGF、CA199、CA724联合使用的AUC（0.894）高于单独使用4项指标；血清TK1、TSGF、CA199、CA724水平较低的胃癌患者预后不良的比例较低；血清TK1、TSGF、CA199、CA724水平是影响胃癌患者预后不良的因素（均P < 0.05）。结论：血清TK1、TSGF、CA199、CA724水平升高与胃癌的临床病理特征及不良预后相关，可作为胃癌患者预后评价的血清生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Surgeon 医学-外科

CiteScore

1.40

自引率

0.00%

发文量

623

期刊介绍： The American Surgeon is a monthly peer-reviewed publication published by the Southeastern Surgical Congress. Its area of concentration is clinical general surgery, as defined by the content areas of the American Board of Surgery: alimentary tract (including bariatric surgery), abdomen and its contents, breast, skin and soft tissue, endocrine system, solid organ transplantation, pediatric surgery, surgical critical care, surgical oncology (including head and neck surgery), trauma and emergency surgery, and vascular surgery.