Bridge over troubled cells: bone marrow stromal cells transfer mitochondria to boost T cells

Abstract

In an article published in Cell in September 2024, Baldwin and colleagues present a bone marrow stromal cell (BMSC) based mitochondrial transfer platform to combat mitochondrial dysfunction or scarcity in human T cells ex-vivo.¹ This thorough and methodically diverse investigation results in a promising technology at a time when adoptive T cell therapies seem to run against a wall of T cell exhaustion and dysfunction in treatments targeting solid tumors.²