Intra-individual Differences in Pericoronary Fat Attenuation Index Measurements Between Photon-counting and Energy-integrating Detector Computed Tomography.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Academic Radiology Pub Date : 2024-12-10 DOI:10.1016/j.acra.2024.11.055

Giuseppe Tremamunno, Milan Vecsey-Nagy, Muhammad Taha Hagar, U Joseph Schoepf, Jim O'Doherty, Julian A Luetkens, Daniel Kuetting, Alexander Isaak, Akos Varga-Szemes, Tilman Emrich, Dmitrij Kravchenko

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引用次数: 0

Abstract

Rationale and objectives: The purpose of this study was to explore intra-individual differences in pericoronary adipose tissue (PCAT) fat attenuation index (FAI) between photon-counting detector (PCD)- and energy-integrating detector (EID)-CT.

Material and methods: Patients were prospectively enrolled for a PCD-CT research scan within 30 days of EID-CT. Both acquisitions were reconstructed using a Qr36 kernel at 0.6 mm slice thickness (EID and PCD-down-sampled [DS]) and at 0.2 mm ultra-high resolution (UHR) for the PCD-CT. Iterative reconstruction was turned "off" (filter back projection used as alternative reconstruction method) or set to a recommended level in current literature. Coronary PCAT FAI was measured automatically using established thresholds of -190 to -30 HU at a set distance and radius. Statistical testing was performed using repeated-measures ANOVA and Bonferroni's multiple comparison tests (p significance was determined to be <0.003).

Results: In total, 40 patients (mean age 68±8 years, 32 males [80%]) were included for analysis. Absolute FAI measurements differed significantly for all vessels between all reconstructions in the ANOVA comparison (all p<.001). The FAI decreased going from EID-CT to PCD-DS, to PCD-UHR with iterative reconstruction turned off (e.g. right coronary artery: EID-CT: -76.5±8.9 vs -80.9±7.0 vs -88.3±6.7 HU, respectively; p < 0.001). The mean FAI of datasets using iterative reconstruction did not demonstrate significant differences on multiple comparisons (e.g. left circumflex artery: EID: -65.7±8.5; PCD-DS: -66.0±7.4; PCD-UHR: -67.8±7.0 HU, respectively; p>0.06).

Conclusion: Intra-individual absolute PCAT FAI measurements differ significantly between EID- and PCD-CT when controlling for reconstruction kernel and slice thickness. However, the use of iterative reconstruction minimizes most differences in FAI, enabling inter-scanner comparability.

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.