OUT-OF-HOSPITAL CARDIAC ARREST ASSOCIATED WITH VENOUS THROMBOEMBOLISM - A SWEDISH POPULATION-BASED COHORT STUDY.

IF 5.5 2区医学 Q1 HEMATOLOGY

Journal of Thrombosis and Haemostasis Pub Date : 2024-12-09 DOI:10.1016/j.jtha.2024.11.021

Emma Bendz, Anna Oksanen, Susanna Larsson, Joel Ohm, Therese Djärv, Maria Bruzelius

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引用次数: 0

Abstract

Background: Venous thromboembolism (VTE) is a common and preventable cardiovascular disease but potentially fatal if presenting as pulmonary embolism. There are few population-based studies on out-of-hospital cardiac arrest (OHCA) associated with VTE.

Objectives: We aimed to investigate the prevalence and survival of VTE-associated OHCA in relation to sex, age and presenting rhythm.

Methods: This population-based cohort included all individuals over 15 years registered with a medical OHCA in Sweden 2008-2018. Data from national registers was used. Association with presenting rhythm, 30-day survival and sex was estimated using adjusted multinomial and binary logistic regression for odds ratios (OR) with 95% confidence interval (CI).

Results: OHCA was associated with VTE in 852 (2.0%) of 41,813 individuals. The median age for VTE-associated OHCA was 69, compared to 73 for the entire cohort, with a higher female prevalence (45% versus 34%). Younger women had a proportionally higher incidence of VTE-associated OHCA than men of the same age. Pulseless electrical activity and asystole had adjusted ORs of 17.2 (CI 11.3-26.0) and 9.59 (CI 6.37-14.4) for VTE-associated OHCA compared with the entire cohort. The 30-day survival was substantially lower in the VTE-group compared to the overall medical OHCA group, 2.0% versus 12%, adjusted OR 0.25 (CI 0.13-0.47).

Conclusion: This nationwide study confirms that VTE-associated OHCA is uncommon and almost always fatal. Despite fewer women experiencing OHCA, a higher proportion had VTE-associated OHCA, especially younger women. Our findings highlight the need for better prevention and identification of VTE-associated OHCA, particularly in women.

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来源期刊

Journal of Thrombosis and Haemostasis 医学-外周血管病

CiteScore

24.30

自引率

3.80%

发文量

321

审稿时长

1 months

期刊介绍： The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.