Paradoxical pyoderma gangrenosum secondary to adalimumab successfully treated with methotrexate: a case report.

Abstract

Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder, categorized under neutrophilic dermatoses. It can be idiopathic or associated with underlying conditions like inflammatory bowel disease, autoimmune diseases, and certain cancers. Some medications, including TNF-alpha inhibitors like adalimumab, can also induce this paradoxical reaction. We describe the case of a 19 year old male with adalimumab induced PG which was successfully treated with methotrexate, contributing to the understanding of drug-induced PG and alternative treatment strategies.