Yang Chen, Qing Zhang, Yinting Hu, Entao Liu, Xiaoyue Tan, Hui Yuan, Lei Jiang
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引用次数: 0
Abstract
Background: The objective of this study is to explore and compare the potential utility of fibroblast activation protein inhibitor (FAPI) and fluorodeoxyglucose PET/computed tomography (CT) in assessing sarcopenia among patients with malignant tumors.
Methods: A retrospective analysis was conducted on 127 patients with histologically confirmed malignant tumors who underwent both 18 F/ 68 Ga-FAPI and fluorine-18-fluorodeoxyglucose ( 18 F-FDG) PET/CT scans. Clinical characteristics and PET/CT parameters of maximum and mean standard uptake value (SUV max and SUV mean ) of muscle at the 3 rd lumbar (L3) level were reviewed. Skeletal muscle area at the L3 level was measured, and skeletal muscle index was calculated to determine sarcopenia. The association between sarcopenia and PET/CT parameters was analyzed.
Results: The incidence of sarcopenia was 41.7% among these 127 patients. Higher age, male, lower BMI, lower SUV max and SUV mean of muscle from 18 F/ 68 Ga-FAPI PET/CT, and lower SUV max of muscle from 18 F-FDG PET/CT were correlated with a higher prevalence of sarcopenia ( P < 0.05). Besides, no significant differences in SUV max and SUV mean of muscle were noted between 18 F-FAPI and 68 Ga-FAPI groups. The best cutoff value of SUV max of muscle from 18 F/ 68 Ga-FAPI PET/CT was 1.17, yielding the area under the curve (AUC) of 0.764 and sensitivity and specificity of 74.3% and 71.7%, while the optimal cutoff value of SUV max of muscle from 18 F-FDG PET/CT was 0.76, with an AUC of 0.642 and sensitivity and specificity of 36.5% and 86.8%, respectively.
Conclusion: Patients with sarcopenia exhibit decreased muscle uptake of FAPI and fluorodeoxyglucose. FAPI PET/CT emerges as a more valuable tool for sarcopenia assessment in patients with malignant tumors compared to fluorodeoxyglucose PET/CT.
期刊介绍：
Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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