Alpha-fetoprotein, glypican-3, and kininogen-1 as biomarkers for the diagnosis of hepatocellular carcinoma.

IF 1.1 Q4 ONCOLOGY

International journal of clinical and experimental pathology Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.62347/QSII4050

Diana Gabriela Domínguez-Lazcano, Ingrid Simón-Lara, Jaime Morales-Romero, Verónica Rocío Vásquez-Garzón, Omar Elind Arroyo-Helguera, Julieta López-Vazquez, Alma D Campos-Parra, Brayan Hernández-Nopaltecatl, Ximena Andrea Rivera-Hernández, Sofía Quintana, Rebeca García-Román

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Abstract

The hepatocarcinoma (HCC) is the most important liver tumor. It represents 90% of liver cancer cases. One of the main problems is the limited prompt cancer diagnosis and the advanced stages where the chances of treatment are limited. The main diagnostic methods for HCC are imaging techniques and liver biopsy. With advances in technology, proteins as significant diagnostic biomarkers have increased. The objective of this review is to describe the role of Alpha-fetoprotein (AFP), Glipican 3 (GPC-3), and Kininogen 1 (KNG-1) as biomarkers for the diagnosis of hepatocellular carcinoma. A systematic search of studies was carried out in the literature and the diagnostic values of these proteins were compared. The results showed that the combined use of biomarkers increases the diagnostic capacity for the detection of hepatocellular carcinoma.

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甲胎蛋白、glypican-3和激肽原-1作为肝细胞癌诊断的生物标志物。

肝癌（HCC）是最重要的肝脏肿瘤。占肝癌病例的90%。其中一个主要问题是癌症的及时诊断有限，而晚期治疗机会有限。肝细胞癌的主要诊断方法是影像学检查和肝活检。随着技术的进步，蛋白质作为重要的诊断生物标志物的地位越来越高。本综述的目的是描述甲胎蛋白（AFP）， Glipican 3 （GPC-3）和Kininogen 1 （KNG-1）作为肝细胞癌诊断的生物标志物的作用。在文献中进行了系统的研究检索，并比较了这些蛋白质的诊断价值。结果表明，生物标志物的联合使用提高了检测肝细胞癌的诊断能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

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0.00%

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审稿时长

1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.