Human albumin infusion and risk of acute kidney injury in adults with nephrotic syndrome due to minimal change disease: A single-center retrospective study.

IF 1.1 4区 医学 Q3 UROLOGY & NEPHROLOGY
Siwei Tang, Siyan Tang, Tong Liu, Xiaolan Chen, Xiayin Li, Yi Liu, Shiren Sun, Peng Zhang, Ming Bai
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引用次数: 0

Abstract

Background: The use of human albumin in patients with minimal change disease (MCD) remains controversial. The aim of the current study was to assess whether infusion of human albumin increased the risk of acute kidney injury (AKI) in adult patients with MCD.

Materials and methods: Adult patients who underwent renal biopsy for the diagnosis of MCD at the center between 2017 and 2022 were screened. Logistic regression and Nelson-Aalen cumulative risk curve analysis were used to compare data from patients with and without human albumin infusion.

Results: A total of 190 adult patients with MCD diagnosed by renal biopsy were included, of whom 45 received human albumin infusion before MCD diagnosis and 34 developed AKI within 4 weeks of MCD diagnosis. Nelson-Aalen cumulative risk curve analysis showed that patients who received human albumin infusion had a longer time to partial or complete response (p < 0.001), were more likely to develop AKI (p < 0.001), and were more likely to relapse (p = 0.002) than those who did not receive human albumin infusion. Multivariate logistic regression analysis showed that human albumin infusion was an independent risk factor for AKI in adult patients with MCD after adjusting for confounding factors (OR = 3.259, 95% CI, 1.209 - 8.780, p = 0.020).

Conclusion: Receiving human albumin infusions may be associated with the development of AKI in adult patients with MCD. Adult MCD patients who received human albumin infusion had a longer time to achieve partial or complete remission and were more likely to relapse.

人白蛋白输注与成人肾病综合征因微小病变引起的急性肾损伤的风险:一项单中心回顾性研究
背景:人白蛋白在微小病变(MCD)患者中的应用仍存在争议。当前研究的目的是评估输注人白蛋白是否会增加MCD成年患者急性肾损伤(AKI)的风险。材料和方法:筛选2017年至2022年间在该中心接受肾活检诊断MCD的成年患者。采用Logistic回归和Nelson-Aalen累积风险曲线分析比较输注人和未输注人白蛋白患者的数据。结果:共纳入190例肾活检诊断为MCD的成年患者,其中45例在MCD诊断前接受了人白蛋白输注,34例在MCD诊断后4周内发生AKI。Nelson-Aalen累积风险曲线分析显示,接受人白蛋白输注的患者达到部分或完全缓解的时间更长(p)。结论:接受人白蛋白输注可能与成年MCD患者AKI的发生有关。接受人白蛋白输注的成年MCD患者达到部分或完全缓解的时间较长,并且更容易复发。
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来源期刊
Clinical nephrology
Clinical nephrology 医学-泌尿学与肾脏学
CiteScore
2.10
自引率
9.10%
发文量
138
审稿时长
4-8 weeks
期刊介绍: Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.
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