Visible-Light-Mediated Nucleophilic Addition of Alkene with Aldehyde: Synthesis of Secondary Alcohols

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-12-10 DOI:10.1021/acs.orglett.4c03819

Du Hu, Haowen Dang, Zhen Liang, Donghao Wang, Yunyun Du, Chao Shen, Jiabin Shen, Min Wang

引用次数: 0

Abstract

Herein, a photocatalytic strategy for the synthesis of secondary alcohols by nucleophilic addition of an alkene with an aldehyde is described. This operationally simple methodology opens an approach for the synthesis of alcohols using commercially available reagents in moderate to excellent yields. Mechanistic studies indicate that the formation of the radical anion from alkene via single-electron transfer is the key step in this reaction.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.