Obesity rather than diabetes impacted severe Covid-19 on reunion island: A retrospective cohort study from a frontline hospital, 2020–2021

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & metabolism Pub Date : 2025-01-01 DOI:10.1016/j.diabet.2024.101601

Yann Brousse , Patrick Gérardin , Dina Filali , Victorine Lenclume , Hind Aissaoui , Marie-Christine Jaffar Bandjee , Estelle Nobecourt , Léa Bruneau

{"title":"Obesity rather than diabetes impacted severe Covid-19 on reunion island: A retrospective cohort study from a frontline hospital, 2020–2021","authors":"Yann Brousse , Patrick Gérardin , Dina Filali , Victorine Lenclume , Hind Aissaoui , Marie-Christine Jaffar Bandjee , Estelle Nobecourt , Léa Bruneau","doi":"10.1016/j.diabet.2024.101601","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>2019-Coronavirus reached the French island of Reunion, which is marked by a very high prevalence of metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM), in March 2020. The objective was to determine the metabolic factors associated with the severity of SARS-CoV-2 infection in Reunion Island.</div></div><div><h3>Methods</h3><div>This retrospective observational cohort study enrolled patients who were hospitalized on the island from March 11th, 2020 to August 4th, 2021. Severe Covid-19 was defined according to the WHO's definition, including deaths. A multilevel logistic model with the circulation period of the variants as a random effect was performed.</div></div><div><h3>Results</h3><div>The median age of the 681 patients enrolled was 56 years [42–68] and 54% were men. Obese patients and patients who were both diabetic and obese had an increased risk of developing severe Covid-19: 2.64 [1.46;4.78] and 2.96 [1.47;5.93], aOR [CI95%] respectively. Diabetic inpatients did not when adjusting for individual characteristics and accounting the period of circulation of variants: 1.24 [0.68;2.24] (<em>P</em> = 0.471).</div></div><div><h3>Conclusion</h3><div>This study reveals an unexpected prominence of obesity on T2DM (without precision) in the development of severe Covid-19. Despite a high prevalence of T2DM, this finding may partially explain why Covid-19 did not have an even greater impact on the island. Further studies should also consider the treatment of diabetes, diabetic complications, glycemic imbalance or stratify by the novel subgroups of T2DM to better understand the link between T2DM and severe Covid-19 in the Reunionese population.</div></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"51 1","pages":"Article 101601"},"PeriodicalIF":4.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & metabolism","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1262363624000922","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

2019-Coronavirus reached the French island of Reunion, which is marked by a very high prevalence of metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM), in March 2020. The objective was to determine the metabolic factors associated with the severity of SARS-CoV-2 infection in Reunion Island.

Methods

This retrospective observational cohort study enrolled patients who were hospitalized on the island from March 11th, 2020 to August 4th, 2021. Severe Covid-19 was defined according to the WHO's definition, including deaths. A multilevel logistic model with the circulation period of the variants as a random effect was performed.

Results

The median age of the 681 patients enrolled was 56 years [42–68] and 54% were men. Obese patients and patients who were both diabetic and obese had an increased risk of developing severe Covid-19: 2.64 [1.46;4.78] and 2.96 [1.47;5.93], aOR [CI95%] respectively. Diabetic inpatients did not when adjusting for individual characteristics and accounting the period of circulation of variants: 1.24 [0.68;2.24] (P = 0.471).

Conclusion

This study reveals an unexpected prominence of obesity on T2DM (without precision) in the development of severe Covid-19. Despite a high prevalence of T2DM, this finding may partially explain why Covid-19 did not have an even greater impact on the island. Further studies should also consider the treatment of diabetes, diabetic complications, glycemic imbalance or stratify by the novel subgroups of T2DM to better understand the link between T2DM and severe Covid-19 in the Reunionese population.

查看原文本刊更多论文

肥胖而不是糖尿病影响留尼旺岛上严重的Covid-19: 2020-2021年一线医院的回顾性队列研究。

2020年3月，冠状病毒到达了法国留尼汪岛，该岛的特点是肥胖和2型糖尿病（T2DM）等代谢紊乱的患病率非常高。目的是确定与留尼汪岛SARS-CoV-2感染严重程度相关的代谢因素。方法：这项回顾性观察队列研究纳入了2020年3月11日至2021年8月4日在岛上住院的患者。根据世界卫生组织的定义，包括死亡在内的严重Covid-19被定义。建立了以变量循环周期为随机效应的多级logistic模型。结果：入组681例患者的中位年龄为56岁[42-68岁]，54%为男性。肥胖患者和糖尿病合并肥胖患者发生重症Covid-19的风险增加：分别为2.64[1.46；4.78]和2.96 [1.47;5.93],aOR [CI95%]。糖尿病住院患者在调整个体特征和计算变异循环周期时没有：1.24 [0.68;2.24]（P = 0.471）。结论：本研究揭示了肥胖在严重Covid-19的发展中出乎意料地突出于T2DM（不精确）。尽管2型糖尿病的患病率很高，但这一发现可能部分解释了为什么Covid-19没有对该岛产生更大的影响。进一步的研究还应考虑糖尿病的治疗、糖尿病并发症、血糖不平衡或按新的T2DM亚组分层，以更好地了解T2DM与朝鲜人群中严重Covid-19之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.